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CyLoP-1 peptide (CRWRWKCCKK)

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Product number: P2292.9505
Delivery time: 3- 8 working days
For detailed information on the delivery date, please contact Genaxxon.

Shipment: not cooled. Store at -20°C. For laboratory usage only!
Product information "CyLoP-1 peptide (CRWRWKCCKK)"

CPPs, such as CyloP-1, are generally taken up by endocytic pathways, with vesicular encapsulation being a limiting factor in intracellular targeting. CyLoP-1 has been developed because it exhibits a pronounced diffuse cytosolic distribution along with endosomal uptake at low micromolar concentrations, thereby enhancing the delivery of a variety of drugs through the membrane barrier.

Cell penetrating peptide (CPPs) are characterised by their ability to promote the receptor-independent cellular uptake of membrane-impermeable macromolecules, such as peptides, proteins, nucleic acids and nanoparticles. CPPs are usually short peptides with less than 30 amino acids. They are mostly amphipathic and highly cationic and usually rich of the amino acids arginine and lysine. Cellular internalisation of CPPs is observed for virtually all cells, although with different efficiencies that depend on the CPP, the cargo and the cell type (Verdurmen and Brock 2011, Trends Pharmacol. Sci. 32, 116-124).

CyloP-1 is a cationic cysteine-rich CPP. Compared to other CPPs, CyloP-1 appeared to be a promising vector for access to the cytosol in a variety of cell types (Bioconjug Chem. 2011 Mar 16;22(3):319-28. doi: 10.1021/bc100045s. Epub 2011 Feb 14. CyLoP-1: a novel cysteine-rich cell-penetrating peptide for cytosolic delivery of cargoes. Jha D1, Mishra R, Gottschalk S, Wiesmüller KH, Ugurbil K, Maier ME, Engelmann J.). In addition to the positively charged residues, the presence of cysteines and tryptophans proved to be essential to maintain its functionality. The distinct feature of CyLoP-1 to enter the cytosol was further explored by the covalent attachment of cargoes of different nature and sizes. In particular, induction of caspase-3 activity (indicating apoptosis) by a CyLoP-1-SmacN7 conjugate proved successful delivery of the pro-apoptotic cargo to its site of action in the cytosol.

Efficient intracellular delivery into the entire cytosol already at low micromolar concentrations makes CyLoP-1 a promising candidate for cytosolic delivery of cargoes of small sizes. Thus, this peptide might prove to be useful for efficient transmembrane delivery of agents directed to cytosolic targets.

Purity: >95% (HPLC)
lyophilized white powder

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eclass-Nr: 32-16-04-09
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Source: NCBI PubMed