Chymotrypsinogen A - Chymotrypsin precursor

Chymotrypsinogen A - Chymotrypsin precursor


Order number: S5230.0005

Shipping: shipped at RT, stored at -20°C
CAS-Nr: 9035-75-0

Delivery time: 3- 8 working days
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Chymotrypsinogen is the practically inactive "precursor" (proenzyme, or zymogen) of... more
Product information "Chymotrypsinogen A - Chymotrypsin precursor"

Chymotrypsinogen is the practically inactive "precursor" (proenzyme, or zymogen) of chymotrypsin. In order to be activated, chymotrypsinogen has to be cleaved by trypsin between the amino acids arginine and isoleucine (R15 and I16) , which leads to structural changes and the formation of the substrate binding site (Sears 2010). Chymotrypsin is a trypsin-like serine protease.

Chymotrypsin differs from trypsin in the selectivity of the cleavage site of proteins. While trypsin cleaves proteins between the amino acids Arg and Lys, Chymotrypsin prefers large hydrophobic amino acids as cleavage site.

Unit definition: The amount of activated zymogen that causes a decrease in absorbance at 237 nm of 0.0075 per minute at 25°C resulting from the hydrolysis of ATEE (NF/USP unit).

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Our comment on "Chymotrypsinogen A - Chymotrypsin precursor"
cleavea proteins at large hydrophobic amino acids
Specifications: pot. Activity: min. 1200 U/mg native activity: min. 7 U/mg (before cleavage by... more
 

Technical Data:

Specifications:
pot. Activity: min. 1200 U/mg
native activity: min. 7 U/mg (before cleavage by Trypsin)
MW = about 25,000 g/mol
Optimal pH: 7.8-8.0 (Rick 1974)

application:

- digestion of proteins and peptides - sequence analysis by edman - peptide mapping

Unit Definition:

One unit is defined as the amount of enzyme that causes a decrease in absorbance at 237nm of 0.0075 per minute at 25°C resulting from the hydrolysis of ATEE (NF/USP unit).

Source

bovine pancreas

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

EC-Nr: 232-905-3
CAS-Nr: 9035-75-0
eclass-Nr: 34-16-05-12
Dokumente - Protokolle - Downloads more

Dokumente - Protokolle - Downloads

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