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[D-Lys3]-GHRP6 (growth hormone releasing peptide 6) induces the secretion of growth hormone (GH). In the membrane of clonal GC somatotropes, this peptide elevates the number of functional voltage-gated Ca2+ and Na+ channels. Chronic treatment with this peptide causes an elevation in Na+ macroscopic current in bovine pituitary somatotropes in culture, which results in an increase in the release of GH.
GH-releasing peptides (GHRPs) are synthetic peptides that like GHRH act directly on pituitary somatotrophs to stimulate GH release. Growth hormone (GH) release is stimulated by a variety of synthetic secretagogues, of which growth hormone-releasing hexapeptide (GHRP-6) has been most thoroughly studied, it is thought to have actions at both pituitary and hypothalamic site.
Synonyms: GHRP-6, GHRP, [D-Lys3]-GHRP-6.
Selective inhibitor of α-MSH activity in frog skin bioassay. Selectively releases growth hormone in vitro and in vivo. Somatostatin antagonist.
Purity: >98.0% (RP-HPLC)
Sequence:: HwAWfK-NH2 (TFA salt)
Sequence (three letter code): H-His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Appearance: white powder
Solution (1mg/mL): Clear and colourless
MW = 930.1 g/mol
application:D-Lys3]-GHRP6 has been used • to treat bovine somatotropes to determine the release of GH from treated cells and non-treated or control cells. • for intraperitoneal injection to groups of broiler chicken to determine the effect on feed intake, weight gain
Sicherheits Hinweise / Safety
Klassifizierungen / ClassificationCAS-Nr: 136054-22-3
Dokumente - Protokolle - Downloads
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