Lipopeptides

Lipoproteins are part of the outer membrane of Gram negative bacteria, Gram positive bacteria, and mycoplasma. Bacterial - including mycoplasmal - lipoproteins (bLP) are characterised by the unusual amino acid dihydroxypropylcysteine (Dhc) acylated by two or three fatty acids. 

Synthetic analogues (sLP) and the N-terminal part of the lipoprotein of E.coli act as potent immunoadjuvants in vivo and in vitro. Immunisation of guinea pigs and swine with a totally synthetic vaccine consisting of the built-in lipotripeptide adjuvant Pam3Cys-Ser-Ser and of a B and T cell epitope of the foot-and-mouth disease virus lead to a long-lasting protection against virus challenge.
The conjugation of class I restricted peptides with Pam3Cys-Ser-Ser resulted in efficient priming of virus-specific cytotoxic T cells for the first time in 1989.

The outer membrane lipoprotein (OspA) from Borrelia burgdorferi was used in human vaccine trials and proved to be protective in a mouse model even after oral immunisation.

Lipoproteins are part of the outer membrane of Gram negative bacteria, Gram positive bacteria, and mycoplasma. Bacterial - including mycoplasmal - lipoproteins (bLP) are characterised by the... read more »
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Lipopeptides

Lipoproteins are part of the outer membrane of Gram negative bacteria, Gram positive bacteria, and mycoplasma. Bacterial - including mycoplasmal - lipoproteins (bLP) are characterised by the unusual amino acid dihydroxypropylcysteine (Dhc) acylated by two or three fatty acids. 

Synthetic analogues (sLP) and the N-terminal part of the lipoprotein of E.coli act as potent immunoadjuvants in vivo and in vitro. Immunisation of guinea pigs and swine with a totally synthetic vaccine consisting of the built-in lipotripeptide adjuvant Pam3Cys-Ser-Ser and of a B and T cell epitope of the foot-and-mouth disease virus lead to a long-lasting protection against virus challenge.
The conjugation of class I restricted peptides with Pam3Cys-Ser-Ser resulted in efficient priming of virus-specific cytotoxic T cells for the first time in 1989.

The outer membrane lipoprotein (OspA) from Borrelia burgdorferi was used in human vaccine trials and proved to be protective in a mouse model even after oral immunisation.

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FSL-1 (Pam2CysGDPKHPKSF) - R-stereoisomer
FSL-1 (Pam2CysGDPKHPKSF) - R-stereoisomer
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
From €225.00 *
FSL-1 (Pam2CysGDPKHPKSF) - R,S-stereoisomer
FSL-1 (Pam2CysGDPKHPKSF) - R,S-stereoisomer
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
From €225.00 *
FSL-1 FLAG-tag TLR2/TLR6 Agonist
FSL-1 FLAG-tag TLR2/TLR6 Agonist
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
From €225.00 *
FSL-1 TLR2/TLR6 Agonist
FSL-1 TLR2/TLR6 Agonist
FSL-1 (Pam2CGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
€445.00 *
FSL-1-Biotin TLR2/TLR6 Peptid
FSL-1-Biotin TLR2/TLR6 Agonist
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
From €225.00 *
FSL-1-Fluorescein TLR2/TLR6 Peptid
FSL-1-Fluorescein TLR2/TLR6 Agonist
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
From €225.00 *
FSL-1-Rhodamin TLR2/TLR6 Peptid
FSL-1-Rhodamine TLR2/TLR6 Agonist
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
From €225.00 *
Lipobiotin
Lipobiotin
Lipobiotin is a selectively biotinylated analogue of PHC-SKKKK. Biotin is attached via spacer molecules to the side chain of the C-terminal lysine. The Biotin-avidin or -streptavidin interaction can be used for detection, labelling or...
From €245.00 *
Lipopeptid Dhc-GDPKHPKSF
Lipopeptid Dhc-GDPKHPKSF
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or FSL-1 are analogues or substructures of TLR2 ligands and...
€282.28 *
Lipopeptide Dhc-SKKKK
Lipopeptide Dhc-SKKKK
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or FSL-1 are analogues or substructures of TLR2 ligands and...
€185.00 *
Lipopeptide GDPKHPKSF
Lipopeptide GDPKHPKSF
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK > , Pam2Cys-SKKKK > or FSL-1 > are analogues or substructures of TLR2 ligands...
€282.28 *
Lipopeptide Pam-Dhc-GDPKHPKSF
Lipopeptide Pam-Dhc-GDPKHPKSF
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or FSL-1 are analogues or substructures of TLR2 ligands and...
€310.00 *
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