Lipopeptides

Lipoproteins are part of the outer membrane of Gram negative bacteria, Gram positive bacteria, and mycoplasma. Bacterial - including mycoplasmal - lipoproteins (bLP) are characterised by the unusual amino acid dihydroxypropylcysteine (Dhc) acylated by two or three fatty acids. 

Synthetic analogues (sLP) and the N-terminal part of the lipoprotein of E.coli act as potent immunoadjuvants in vivo and in vitro. Immunisation of guinea pigs and swine with a totally synthetic vaccine consisting of the built-in lipotripeptide adjuvant Pam3Cys-Ser-Ser and of a B and T cell epitope of the foot-and-mouth disease virus lead to a long-lasting protection against virus challenge.
The conjugation of class I restricted peptides with Pam3Cys-Ser-Ser resulted in efficient priming of virus-specific cytotoxic T cells for the first time in 1989.

The outer membrane lipoprotein (OspA) from Borrelia burgdorferi was used in human vaccine trials and proved to be protective in a mouse model even after oral immunisation.

Lipoproteins are part of the outer membrane of Gram negative bacteria, Gram positive bacteria, and mycoplasma. Bacterial - including mycoplasmal - lipoproteins (bLP) are characterised by the... read more »
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Lipopeptides

Lipoproteins are part of the outer membrane of Gram negative bacteria, Gram positive bacteria, and mycoplasma. Bacterial - including mycoplasmal - lipoproteins (bLP) are characterised by the unusual amino acid dihydroxypropylcysteine (Dhc) acylated by two or three fatty acids. 

Synthetic analogues (sLP) and the N-terminal part of the lipoprotein of E.coli act as potent immunoadjuvants in vivo and in vitro. Immunisation of guinea pigs and swine with a totally synthetic vaccine consisting of the built-in lipotripeptide adjuvant Pam3Cys-Ser-Ser and of a B and T cell epitope of the foot-and-mouth disease virus lead to a long-lasting protection against virus challenge.
The conjugation of class I restricted peptides with Pam3Cys-Ser-Ser resulted in efficient priming of virus-specific cytotoxic T cells for the first time in 1989.

The outer membrane lipoprotein (OspA) from Borrelia burgdorferi was used in human vaccine trials and proved to be protective in a mouse model even after oral immunisation.

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FSL-1 (Pam2CysGDPKHPKSF) - R-stereoisomer FSL-1 (Pam2CysGDPKHPKSF) - R-stereoisomer
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
From €238.70 *
FSL-1 (Pam2CysGDPKHPKSF) - R,S-stereoisomer FSL-1 (Pam2CysGDPKHPKSF) - R,S-stereoisomer
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
From €238.70 *
FSL-1 FLAG-tag TLR2/TLR6 Agonist FSL-1 FLAG-tag TLR2/TLR6 Agonist
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
From €238.70 *
FSL-1 TLR2/TLR6 Agonist FSL-1 TLR2/TLR6 Agonist
FSL-1 (Pam2CGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
€472.10 *
FSL-1-Biotin TLR2/TLR6 Peptid FSL-1-Biotin TLR2/TLR6 Agonist
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
From €238.70 *
FSL-1-Fluorescein TLR2/TLR6 Peptid FSL-1-Fluorescein TLR2/TLR6 Agonist
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
From €238.70 *
FSL-1-Rhodamin TLR2/TLR6 Peptid FSL-1-Rhodamine TLR2/TLR6 Agonist
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
From €238.70 *
Lipobiotin - PHC-KKKKK(Biotin-Aca-Aca) Lipobiotin - PHC-KKKKK(Biotin-Aca-Aca)
Lipobiotin - PHC-KKKKK(Biotin-Aca-Aca) is a selectively biotinylated analogue of PHC-SKKKK ( P2232 > ). Biotin is attached via spacer molecules to the side chain of the C-terminal lysine. The Biotin-avidin or -streptavidin interaction...
From €259.92 *
Lipopeptid Dhc-GDPKHPKSF Lipopeptid Dhc-GDPKHPKSF
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or FSL-1 are analogues or substructures of TLR2 ligands and...
€299.47 *
Lipopeptide Dhc-SKKKK Lipopeptide Dhc-SKKKK
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or FSL-1 are analogues or substructures of TLR2 ligands and...
€196.27 *
Lipopeptide GDPKHPKSF Lipopeptide GDPKHPKSF
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK > , Pam2Cys-SKKKK > or FSL-1 > are analogues or substructures of TLR2 ligands...
€299.47 *
Lipopeptide Pam-Dhc-GDPKHPKSF Lipopeptide Pam-Dhc-GDPKHPKSF
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or FSL-1 are analogues or substructures of TLR2 ligands and...
€328.88 *
Lipopeptide Pam-Dhc-SKKKK Lipopeptide Pam-Dhc-SKKKK
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or FSL-1 are analogues or substructures of TLR2 ligands and...
€217.48 *
Lipopeptide PamCGDPKHPKSF Lipopeptide PamCGDPKHPKSF
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or FSL-1 are analogues or substructures of TLR2 ligands and...
€355.40 *
Lipopeptide PamCSKKKK Lipopeptide PamCSKKKK
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or FSL-1 are analogues or substructures of TLR2 ligands and...
€217.48 *
Lipopeptide SKKKK Lipopeptide SKKKK
Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or FSL-1 are analogues or substructures of TLR2 ligands and...
€206.88 *
MALP-2-DI (Pam2Cys-GNNDESNISFKEKDI) Peptide MALP-2-DI (Pam2CysGNNDESNISFKEKDI) -...
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
€477.41 *
MALP-2-DI (Pam2Cys-GNNDESNISFKEKDI) Peptide MALP-2-DI (Pam2CysGNNDESNISFKEKDI) -...
FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was...
€381.92 *
Lipopeptide Pam2Cys-SKKKK Pam2Cys-SKKKK
Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on L-cysteine and are provided as lyophilised powders without any...
From €153.83 *
Pam2Cys-SKKKK-Flag peptide Pam2Cys-SKKKK-FLAG-tag
Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on L-cysteine and are provided as lyophilised powders without any...
From €238.70 *
Pam2Cys-SKKKK(Biotin-Aca-Aca)-NH2 Pam2Cys-SKKKK(Biotin-Aca-Aca)-NH2
Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on L-cysteine and are provided as lyophilised powders without any...
From €238.70 *
Pam2Cys-SKKKK(Fluorescein-Aca-Aca)-NH2 Pam2Cys-SKKKK(Fluorescein-Aca-Aca)-NH2
Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on L-cysteine and are provided as lyophilised powders without any...
From €238.70 *
Pam2Cys-SKKKK(Rhodamine-Aca-Aca)-NH2 Pam2Cys-SKKKK(Rhodamine-Aca-Aca)-NH2
Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on L-cysteine and are provided as lyophilised powders without any...
From €238.70 *
Pam3Cys-SKKKK Pam3Cys-SKKKK
Pam3Cys-SKKKK is the mostly used synthetic analogue of naturally occurring lipoproteins and often described in literature as reference compound for TLR2/1 activation. Pam3Cys-SKKKK is provided as stereochemically defined compound and as...
From €188.84 *
Pam3Cys-SKKKK (Aca-Aca-Biotin) Pam3Cys-SKKKK (Aca-Aca-Biotin)
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
From €238.70 *
Pam3Cys-SKKKK (Fluorescein-Aca-Aca) Pam3Cys-SKKKK (Fluorescein-Aca-Aca)
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
From €238.70 *
Pam3Cys-SKKKK (Rhodamin-Aca-Aca) Pam3Cys-SKKKK (Rhodamin-Aca-Aca)
Triacyl-Lipopeptid. The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins...
From €238.70 *
Pam3Cys-SKKKK-FLAG-tag Pam3Cys-SKKKK-FLAG-tag
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
From €238.70 *
Pam3CysAQEKEAKSELDYDQT Pam3CysAQEKEAKSELDYDQT
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
€493.32 *
Pam3CysGSHQMKSEGHANMQL Pam3CysGSHQMKSEGHANMQL
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
€482.71 *
Pam3CysKQNVSSLDEKNSVSV Pam3CysKQNVSSLDEKNSVSV
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
€482.71 *
Pam3CysNNGGPELKSDEVAKS Pam3CysNNGGPELKSDEVAKS
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
€482.71 *
Pam3CysNNSGKDGNTSANSAD Pam3CysNNSGKDGNTSANSAD
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
€482.71 *
Pam3CysSQEPAAPAAEATPAG Pam3CysSQEPAAPAAEATPAG
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
€482.71 *
Lipopeptide Pam3CysSSGNKSAPSSSASSS Pam3CysSSGNKSAPSSSASSS
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
€482.71 *
Lipopeptide Pam3CysSSGSKPSGGPLPDAK Pam3CysSSGSKPSGGPLPDAK
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
€482.71 *
Lipopeptide Pam3CysSSNAKIDQLSSDVQT Pam3CysSSNAKIDQLSSDVQT
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
€482.71 *
Lipopeptide Pam3CysSSNKSTTGSGETTTA Pam3CysSSNKSTTGSGETTTA
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
€482.71 *
Pam3CysSSSKSSDSSAPKAYG Pam3CysSSSKSSDSSAPKAYG
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
€477.41 *
Pam3CysSSSNNDAAGNGAAQT Pam3CysSSSNNDAAGNGAAQT
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
€482.71 *
Lipopeptide Pam3CysSSTKPVSQDTSPKPA Pam3CysSSTKPVSQDTSPKPA
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
€482.71 *
PamCys(Pam)-SKKKK PamCys(Pam)-SKKKK
Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on L-cysteine and are provided as lyophilised powders without any...
From €238.70 *
PHC-SKKKK PHC-SKKKK
Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on L-cysteine and are provided as lyophilised powders without any...
€217.48 *
R-Pam2Cys-SKKKK R-Pam2Cys-SKKKK
Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on L-cysteine and are provided as lyophilised powders without any...
From €238.70 *
R-Pam3Cys-SKKKK R-Pam3Cys-SKKKK
The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins see attachement....
From €238.70 *
S-Pam2Cys-SKKKK S-Pam2Cys-SKKKK
Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on L-cysteine and are provided as lyophilised powders without any...
From €238.70 *
S-Pam3Cys-SKKKK S-Pam3Cys-SKKKK
Triacyl-Lipopeptid. The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated. For a complete list of all lipoproteins...
From €238.70 *
Lipopeptide FSL-1 FLAG-tag Lipopeptid PamCys Pam Pam2Cys-SKKKK Pam3CysSSSNNDAA FSL-1-Rhodamine Pam3Cys-SKKKK Pam3Cys-SKKKK-F Pam3Cys-SKKKK Lipopeptide Pam3CysNNGGPELK Pam3CysAQEKEAKS FSL-1-Biotin Pam3Cys-SKKKK PHC-SKKKK Lipobiotin - Pam3CysSSTKPVSQ Pam3CysSSGNKSAP FSL-1 TLR2 TLR6 FSL-1 S-Pam3Cys-SKKKK Pam3CysSQEPAAPA R-Pam2Cys-SKKKK Lipopeptide MALP-2-DI Lipopeptide Pam3CysSSNKSTTG Lipopeptide Pam2Cys-SKKKK Pam3CysNNSGKDGN Pam3Cys-SKKKK Pam3CysSSGSKPSG S-Pam2Cys-SKKKK Lipopeptide FSL-1-Fluoresce Pam3CysSSNAKIDQ Pam2Cys-SKKKK Pam3CysGSHQMKSE Pam3CysSSSKSSDS Lipopeptide FSL-1 Pam2Cys-SKKKK-F R-Pam3Cys-SKKKK Pam3CysKQNVSSLD Pam2Cys-SKKKK
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