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FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was shown that the activity of FSL-1 is TLR2 and TLR6 dependent. A single amino acid substitution from F to R (FSL-2, Pam2Cys-GDPKHPKSR, Cat-No- P2219 >) reduced the activity significantly (Okusawa et al. 2004). FSL-1 (P2212) > is more favourable than MALP-2 with respect to solubility in aqueous solutions. FSL-1 is provided as stereochemically defined compounds and as mixture of stereoisomers. Lipopeptides with the S-dihydroxypropyl moiety are not active and therefore suitable as negative controls. Additionally, analogues with different labels or tags are available. Genaxxon offers further analogues differing in the peptide moiety for improved physico-chemical features and high reproducible biological activity. Please inquire for other peptides or more information: firstname.lastname@example.org.
Lipopeptides are very hydrophobic peptides. For this reason it is most often not possible to purify them by HPLC and to give reliable purity values (in %) for our standard lipopeptides.
Sequence (three letter code: Pam2Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe
chemical formula: C84H140N14O18S
MW = 1665 g/mol
The naturally occurring RR-stereoisomer of Pam2Cys, R-Pam2Cys, is described to be biologically more active than the S-stereoisomer S-[2,3-bis(palmitoyloxy)-2(S)-propyl]-(R)-cysteine.
Sicherheits Hinweise / Safety
Klassifizierungen / Classificationeclass-Nr: 34-16-04-90
Dokumente - Protokolle - Downloads
Here you will find information and further literature on FSL-1 (Pam2CysGDPKHPKSF) - R-stereoisomer. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: email@example.com or phone: +49 731 3608 123.