FSL-1-Biotin TLR2/TLR6 Agonist



Order number: P2215.0100

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FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to... more
Product information "FSL-1-Biotin TLR2/TLR6 Agonist"

FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2 and TLR6 to produce NF-kappaB (Okusawa et al. 2004). It was shown that the activity of FSL-1 is TLR2 and TLR6 dependent. A single amino acid substitution from F to R (FSL-2, Pam2Cys-GDPKHPKSR, Cat-No- P2219) reduced the activity significantly (Okusawa et al. 2004). FSL-1 (P2212) is more favourable than MALP-2 with respect to solubility in aqueous solutions. FSL-1 is provided as stereochemically defined compounds and as mixture of stereoisomers. Lipopeptides with the S-dihydroxypropyl moiety are not active and therefore suitable as negative controls. Additionally, analogues with different labels or tags are available. Genaxxon offers further analogues differing in the peptide moiety for improved physico-chemical features and high reproducible biological activity. Please inquire for other peptides or more information: info@genaxxon.com.

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Specifications: Lipopeptides are very hydrophobic peptides. For this reason it is most often... more
 

Technical Data:

Specifications:
Lipopeptides are very hydrophobic peptides. For this reason it is most often not possible to purify them by HPLC and to give reliable purity values (in %) for our standard lipopeptides.
Sequence: Pam2CysGDPKHPKSF
mixture of R,R and R,S stereoisomers

Source

synthetic

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

eclass-Nr: 34-16-04-90
Dokumente - Protokolle - Downloads more

Dokumente - Protokolle - Downloads

Here you will find information and further literature on FSL-1-Biotin TLR2/TLR6 Agonist. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.