Order number: P2275.9505Shipping: shipped at RT, store at -20°C
CAS-Nr: 138831-86-4 (free base)
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Ovalbumin (257-264) chicken has been used to trigger T cell activation in immunology studies.
T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are typically peptides between 8 and 11 amino acids in length and exhibiting MHC-specific sequence motifs. These antigenic peptides are derived from non-structural and structural proteins through proteolysis in the cytosolic compartment. Peptide-MHC-I complexes are then transported to the cell surface of antigen presenting cells and are recognised by CD8+ cytotoxic T lymphocytes (CTL). This interaction induces the differentiation of CTLs. Activated CTL lyse the infected cell, secrete cytokines, and proliferate. This mechanism ensures that cells infected by viruses or intracellular bacteria or cancer cells can be detected, since pathogen or cancer-specific MHC peptide complexes are displayed on the cell surface. CTL can recognise such abnormal cells and eliminate them. The genes of MHC I and II molecules are polymorphic. Each MHC allele has a distinct peptide binding motif which favours certain amino acid anchor residues at defined sequence positions.
Purity: >95% (HPLC, 214 nm)
Sequence (three letter code: H - Ser - Ile - Ile - Asn - Phe - Glu - Lys - Leu - OH
MW = 963.13 g/mol
C45H74N10O13 x C2HF3O2
Sicherheits Hinweise / Safety
Klassifizierungen / ClassificationCAS-Nr: 138831-86-4 (free base)
Dokumente - Protokolle - Downloads
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Quelle/Source: NCBI PubMed >
Wibke Bayer, Matthias Tenbusch, Ruth Lietz, Lena Johrden, Simone Schimmer, Klaus Überla, Ulf Dittmer, Oliver Wildner
J Virol. 2010 Feb; 84(4): 1967–1976. Published online 2009 Dec 9. doi: 10.1128/JVI.01840-09
Coexpression of GM-CSF and antigen in DNA prime-adenoviral vector boost immunization enhances polyfunctional CD8+ T cell responses, whereas expression of GM-CSF antigen fusion protein induces autoimmunity
Matthias Tenbusch, Seraphin Kuate, Bettina Tippler, Nicole Gerlach, Simone Schimmer, Ulf Dittmer, Klaus Überla
BMC Immunol. 2008; 9: 13. Published online 2008 Apr 11. doi: 10.1186/1471-2172-9-13