Ova (257-264) SIINFEKL

OVA peptide SIINFEKL


Order number: P2275.9505

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CAS-Nr: 138831-86-4 (free base)

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Ovalbumin (257-264) chicken has been used to trigger T cell activation in immunology studies.... more
Product information "Ova (257-264) SIINFEKL"

Ovalbumin (257-264) chicken has been used to trigger T cell activation in immunology studies.

T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are typically peptides between 8 and 11 amino acids in length and exhibiting MHC-specific sequence motifs. These antigenic peptides are derived from non-structural and structural proteins through proteolysis in the cytosolic compartment. Peptide-MHC-I complexes are then transported to the cell surface of antigen presenting cells and are recognised by CD8+ cytotoxic T lymphocytes (CTL). This interaction induces the differentiation of CTLs. Activated CTL lyse the infected cell, secrete cytokines, and proliferate. This mechanism ensures that cells infected by viruses or intracellular bacteria or cancer cells can be detected, since pathogen or cancer-specific MHC peptide complexes are displayed on the cell surface. CTL can recognise such abnormal cells and eliminate them. The genes of MHC I and II molecules are polymorphic. Each MHC allele has a distinct peptide binding motif which favours certain amino acid anchor residues at defined sequence positions.

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Specifications: Purity: >95% (HPLC, 214 nm) Sequence: SIINFEKL Sequence (three letter... more
 

Technical Data:

Specifications:
Purity: >95% (HPLC, 214 nm)
Sequence: SIINFEKL
Sequence (three letter code: H - Ser - Ile - Ile - Asn - Phe - Glu - Lys - Leu - OH
MW = 963.13 g/mol
C45H74N10O13 x C2HF3O2

Source

synthetic

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

CAS-Nr: 138831-86-4 (free base)
eclass-Nr: 34-16-04-90
Dokumente - Protokolle - Downloads more

Dokumente - Protokolle - Downloads

Here you will find information and further literature on Ova (257-264) SIINFEKL. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.

 
 
 
Literatur .... more

Referenzen..

Hier finden Sie Artikel und Literaturzitate, in denen die Autoren auf die hohe Qualität dieses Genaxxonprodukts vertrauen.
Listed below are articles and references, in which the authors trust in the high quality of this Genaxxon product.

Quelle/Source: NCBI PubMed >

 

Vaccination with an Adenoviral Vector That Encodes and Displays a Retroviral Antigen Induces Improved Neutralizing Antibody and CD4+ T-Cell Responses and Confers Enhanced Protection

 

Wibke Bayer, Matthias Tenbusch, Ruth Lietz, Lena Johrden, Simone Schimmer, Klaus Überla, Ulf Dittmer, Oliver Wildner

 

J Virol. 2010 Feb; 84(4): 1967–1976.  Published online 2009 Dec 9. doi: 10.1128/JVI.01840-09

 

PMCID: PMC2812386

Coexpression of GM-CSF and antigen in DNA prime-adenoviral vector boost immunization enhances polyfunctional CD8+ T cell responses, whereas expression of GM-CSF antigen fusion protein induces autoimmunity

Matthias Tenbusch, Seraphin Kuate, Bettina Tippler, Nicole Gerlach, Simone Schimmer, Ulf Dittmer, Klaus Überla

BMC Immunol. 2008; 9: 13.  Published online 2008 Apr 11. doi: 10.1186/1471-2172-9-13

PMCID: PMC2324072