Ova (257-264) SIINFEKL amide
Order number: P3286.9505
Shipping: shipped at RT, store at -20°CCAS-Nr: 138831-86-4 (free base)
Delivery time: 3- 8 working days
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Quantity | Unit price |
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From 3 | €157.50 * |
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Ovalbumin (257-264) chicken has been used to trigger T cell activation in immunology studies.
T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are typically peptides between 8 and 11 amino acids in length and exhibiting MHC-specific sequence motifs. These antigenic peptides are derived from non-structural and structural proteins through proteolysis in the cytosolic compartment. Peptide-MHC-I complexes are then transported to the cell surface of antigen presenting cells and are recognised by CD8+ cytotoxic T lymphocytes (CTL). This interaction induces the differentiation of CTLs. Activated CTL lyse the infected cell, secrete cytokines, and proliferate. This mechanism ensures that cells infected by viruses or intracellular bacteria or cancer cells can be detected, since pathogen or cancer-specific MHC peptide complexes are displayed on the cell surface. CTL can recognise such abnormal cells and eliminate them. The genes of MHC I and II molecules are polymorphic. Each MHC allele has a distinct peptide binding motif which favours certain amino acid anchor residues at defined sequence positions.
Technical Data:
Specifications:
Purity: >95% (HPLC, 214 nm)
Sequence: SIINFEKL-NH2
Sequence (three letter code): H - Ser - Ile - Ile - Asn - Phe - Glu - Lys - Leu - NH2
MW = 963.13 g/mol
C45H75N11O12 x C2HF3O2
Source
syntheticSicherheits Hinweise / Safety
Klassifizierungen / Classification
CAS-Nr: 138831-86-4 (free base)eclass-Nr: 34-16-04-90
Dokumente - Protokolle - Downloads
Here you will find information and further literature on Ova (257-264) SIINFEKL amide. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.
Referenzen..
Hier finden Sie Artikel und Literaturzitate, in denen die Autoren auf die hohe Qualität dieses Genaxxonprodukts vertrauen.
Listed below are articles and references, in which the authors trust in the high quality of this Genaxxon product.
Quelle/Source: NCBI PubMed >
Wibke Bayer, Matthias Tenbusch, Ruth Lietz, Lena Johrden, Simone Schimmer, Klaus Überla, Ulf Dittmer, Oliver Wildner
J Virol. 2010 Feb; 84(4): 1967–1976. Published online 2009 Dec 9. doi: 10.1128/JVI.01840-09
PMCID: PMC2812386
Matthias Tenbusch, Seraphin Kuate, Bettina Tippler, Nicole Gerlach, Simone Schimmer, Ulf Dittmer, Klaus Überla
BMC Immunol. 2008; 9: 13. Published online 2008 Apr 11. doi: 10.1186/1471-2172-9-13
PMCID: PMC2324072