SARS-CoV-2 (2019-nCoV) Spike S1 Protein (RBD)

SARS-CoV-2 (2019-nCoV) Spike S1 Protein (RBD)


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The SARS-CoV-2 genome encodes for a spike protein, an envelope protein, a Introduction... more
Product information "SARS-CoV-2 (2019-nCoV) Spike S1 Protein (RBD)"

The SARS-CoV-2 genome encodes for a spike protein, an envelope protein, a Introduction membrane protein, and a nucleoprotein. The spike (S) glycoprotein of coronaviruses is essential for binding of the virus to the host cell at the beginning of the infection process. Of particular note is the amino acid sequence Arg-Gly-Asp (RGD) at position 403-405 of the spike protein. These 3 amino acids are conserved in all known SARS-Co-2 viruses, but not in other types of coronavirus.

Outside of SARS-CoV-2, the RGD sequence occurs particularly in proteins of the extracellular matrix (connective tissue), for example in fibronectin and vitronectin. This enables cells to bind to the RGD sequence with the help of certain cell surface receptors, the integrins. In addition to the SARS-CoV-2 viruses, well-known viruses such as HMPV, HCV or EBV also use the RGD to penetrate the cell.

The SARS-CoV-2 spike (S) glycoprotein is responsible for membrane fusion and is therefore required for cell fusion and virus entry. The spike protein is also a major immunogen and a possible target for inhibitors.

The SARS-CoV-2 spike (S) protein is a large type I transmembrane protein composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain (RBD) responsible for binding to the host cell receptor angiotensin-converting enzyme 2 (ACE2). The S2 subunit mediates fusion between the viral and host cell membranes. The S1 RBD protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Protein sequence:
RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKV
GGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF

RefSeq Links: NC_045512.2 ; MN908947.3; YP_009724390.1 ; QHD43416.1 ; GeneID: 43740568

SARS-CoV-2 (2019-nCoV) Spike S1 Protein can be used for the development of diagnostic kits. It is not for direct detection of SARS-Cov-2. The counterpart to SARS-CoV-2 is ACE2 (angiotensin converting enzyme-2), which has previously been described as a receptor for SARS-CoV.

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Specifications: Species: Wuhan seafood market pneumonia virus; 2019-nCoV Purity: >90%... more
 

Technical Data:

Specifications:
Species: Wuhan seafood market pneumonia virus; 2019-nCoV
Purity: >90% as determined by SDS-PAGE
C-terminal His-Tag

Expression host: human, HEK293

Source

HEK293

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

eclass-Nr: 34-16-04-90
Dokumente - Protokolle - Downloads more


Dokumente - Protokolle - Downloads

Here you will find information and further literature on SARS-CoV-2 (2019-nCoV) Spike S1 Protein (RBD). For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.