SARS-CoV-2 Spike S1 Protein (RBD) with His-Tag
Order number: S5340.0100Shipping: shipped on wet ice, stored at -80°C
Delivery time: 3- 8 working days
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SARS-CoV-2 Spike Protein RBD Recombinant with C-terminal His-tag is a recombinant protein that is in liquid form buffered in PBS. This protein was produced recombinantly and is HIS-tagged at the C-terminus.This receptor binding domain (RBD) of the SARS-CoV-2 spike protein is a 223 amino acid glycoprotein corresponding to positions 319-541 of the S1 sequence of the spike protein. RGD stands for the amino acid sequence: Arg-Gly-Asp (RGD) in position 403-405 of the spike protein. These 3 amino acids are conserved across all known SARS Co-2 sequences, but not in other coronaviruses.
Cells expressing ACE2 (angiotensin converting enzyme 2) are infected by SARS-CoV-2. ACE2 binds as a cellular receptor to the viral spike protein (S) after proteolytic cleavage. The receptor-binding domain (RBD) of the S protein is the domain that specifically binds to ACE2. The S1-RBD protein plays a key role in the induction of neutralising antibody and T-cell responses and the establishment of protective immunity.
Sequence without tags (AA 319-541):
RefSeq Links: NC_045512.2 ; MN908947.3; YP_009724390.1 ; QHD43416.1 ; GeneID: 43740568
SARS-CoV-2 (2019-nCoV) Spike S1 Protein can be used for the development of diagnostic kits. It is not for direct detection of SARS-Cov-2. The counterpart to SARS-CoV-2 is ACE2 (angiotensin converting enzyme-2), which has previously been described as a receptor for SARS-CoV.
Formulation: PBS, pH7.4
Format: Liquid, stored and shipped at -80°C
Purity: >85% as determined by SDS-PAGE
with C-terminal His-Tag
MW: about 40 kDa
Expression host: human, HEK293
Species: Wuhan seafood market pneumonia virus; 2019-nCoV
Sicherheits Hinweise / Safety
Klassifizierungen / Classificationeclass-Nr: 34-16-04-90
Dokumente - Protokolle - Downloads
Here you will find information and further literature on SARS-CoV-2 Spike S1 Protein (RBD) with His-Tag. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: firstname.lastname@example.org or phone: +49 731 3608 123.