recombinant human ACE2 Protein (ECD), Avi/His-Tag, non-biotinylated



Order number: S5344.0100

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Recombinant human ACE2 Protein (ECD processed) contains an Avi/His-Tag, and is ready for invitro... more
Product information "recombinant human ACE2 Protein (ECD), Avi/His-Tag, non-biotinylated"

Recombinant human ACE2 Protein (ECD processed) contains an Avi/His-Tag, and is ready for invitro biotinylation. We offer high purity. and quality in HEK293 expressed recombinant protein for R&D made in Germany. As SARS-CoV.2 uses ACE2 as the entry point into cells it is one of the most important components to develop effective COVID-19 therapeutics.

The human Angiotensin-Converting Enzyme 2 (hACE2) is a type I transmembrane metallocarboxy-peptidase with homology to ACE, a regulator in the Renin-Angiontensin system (RAS). hACE2 is expressed at the surface of cells of all tissues shown to harbour SARS-CoV, as human lungs, arteries, kidneys, heart, and intestine.

ACE-2 is known to control blood pressure by the hydrolysis of a small peptide hormone called Angiotensin II into Angiotensin 1-7 by ACE and other endopeptidases, Angiontensin 1-7 acts in a vasoconstricting manner and is therefore involved in diabetes, hypertension, and cardiac function in general. SARS-CoV.2 uses ACE2 as the entry point into alveolar cells of the lungs, where it replicates and causes the Coronavirus disease (COVID-19).

Sequence without tags (AA 20-707, about 80 kDa):

MTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSSGGLNDIFEAQKIEWHEGSGHHHHHHHHG

Methionin at position 1 present due to cloning constraints. This Methionin does not belong to the ACE 2 protein sequence.

RefSeq Links: UniProt: Q9BYF1

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Specifications: Purification method: purified by IEC Purity: >90% as determined by... more
 

Technical Data:

Specifications:
Purification method: purified by IEC
Purity: >90% as determined by SDS-PAGE
Tag(s): Tag: Avi/His-Tag, C-terminal. Avi-Tag not biotinylated
Formulation: dissolved in PBS, pH7.4

Expression host: human, HEK293

Source

human, HEK293

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

eclass-Nr: 34-16-04-90
Dokumente - Protokolle - Downloads more


Dokumente - Protokolle - Downloads

Here you will find information and further literature on recombinant human ACE2 Protein (ECD), Avi/His-Tag, non-biotinylated. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.