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SARS-CoV-2 Spike S1 Protein (RBD) - without Tag

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€304.62*

Weight
Product number: S5334.0100
Delivery time: 3- 8 working days
For detailed information on the delivery date, please contact Genaxxon.

Shipment: on wet ice. Store at -20°C. For laboratory usage only!
Product information "SARS-CoV-2 Spike S1 Protein (RBD) - without Tag"

SARS-CoV-2 Spike Protein RBD Recombinant without His-tag is a recombinant protein that is in liquid form buffered in PBS. This protein was produced recombinantly and is HIS-tagged at the C-terminus.

This receptor binding domain (RBD) of the SARS-CoV-2 spike protein is a 223 amino acid glycoprotein corresponding to positions 319-541 of the S1 sequence of the spike protein. Cells expressing ACE2 (angiotensin converting enzyme 2) are infected by SARS-CoV-2. ACE2 binds as a cellular receptor to the viral spike protein (S) after proteolytic cleavage. The receptor-binding domain (RBD) of the S protein is the domain that specifically binds to ACE2. The S1-RBD protein plays a key role in the induction of neutralising antibody and T-cell responses and the establishment of protective immunity. RGD stands for the amino acid sequence: Arg-Gly-Asp (RGD) in position 403-405 of the spike protein. These 3 amino acids are conserved across all known SARS Co-2 sequences, but not in other coronaviruses.

Protein sequence:
Sequence without tags (AA 319-541):
RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKV
GGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF

RefSeq Links: NC_045512.2 ; MN908947.3; YP_009724390.1 ; QHD43416.1 ; GeneID: 43740568; UniProt: PoDTC2

SARS-CoV-2 (2019-nCoV) Spike S1 Protein can be used for the development of diagnostic kits. It is not for direct detection of SARS-Cov-2. The counterpart to SARS-CoV-2 is ACE2 (angiotensin converting enzyme-2), which has previously been described as a receptor for SARS-CoV.

Specifications:
Formulation: PBS, pH7.4
Format: Liquid, stored and shipped at -80°C
Purity: >90% as determined by SDS-PAGE
C-terminal: no tag
MW: about 40 kDa

Expression host: CHO
Species: Wuhan seafood market pneumonia virus; 2019-nCoV


Applikation / Application:
Einheiten / Units:
Quelle / Source:
CHO


Sicherheits Hinweise / Safety


Klassifizierungen / Classification

eclass-Nr: 32-16-04-09
Documents - Protocols - Downloads :
Here you will find information and further literature. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.


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Listed below are articles and references, in which the authors trust in the high quality of this Genaxxon product.
Source: NCBI PubMed