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Lipopeptides

Lipoproteins are part of the outer membrane of Gram negative bacteria, Gram positive bacteria, and mycoplasma. Bacterial - including mycoplasmal - lipoproteins (bLP) are characterised by the unusual amino acid dihydroxypropylcysteine (Dhc) acylated by two or three fatty acids. 

Synthetic analogues (sLP) and the N-terminal part of the lipoprotein of E.coli act as potent immunoadjuvants in vivo and in vitro. Immunisation of guinea pigs and swine with a totally synthetic vaccine consisting of the built-in lipotripeptide adjuvant Pam3Cys-Ser-Ser and of a B and T cell epitope of the foot-and-mouth disease virus lead to a long-lasting protection against virus challenge.
The conjugation of class I restricted peptides with Pam3Cys-Ser-Ser resulted in efficient priming of virus-specific cytotoxic T cells for the first time in 1989.

The outer membrane lipoprotein (OspA) from Borrelia burgdorferi was used in human vaccine trials and proved to be protective in a mouse model even after oral immunisation.

   
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FSL-1 (Pam2CysGDPKHPKSF) - R-stereoisomer

FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with...

From €225.00 *

FSL-1 (Pam2CysGDPKHPKSF) - R,S-stereoisomer

FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with...

From €225.00 *

FSL-1 FLAG-tag TLR2/TLR6 Agonist

FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with...

From €225.00 *

FSL-1 TLR2/TLR6 Agonist

FSL-1 (Pam2CGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with TLR2...

€445.00 *

FSL-1-Biotin TLR2/TLR6 Agonist

FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with...

From €225.00 *

FSL-1-Fluorescein TLR2/TLR6 Agonist

FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with...

From €225.00 *

FSL-1-Rhodamine TLR2/TLR6 Agonist

FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with...

From €225.00 *

No image available Lipobiotin

Lipobiotin is a selectively biotinylated analogue of PHC-SKKKK. Biotin is attached via spacer molecules to the side chain of the C-terminal lysine. The Biotin-avidin or...

From €225.00 *

Lipopeptid Dhc-GDPKHPKSF

Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or...

€282.28 *

Lipopeptide Dhc-SKKKK

Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or...

€170.95 *

No image available Lipopeptide GDPKHPKSF

Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or...

€282.28 *

Lipopeptide Pam-Dhc-GDPKHPKSF

Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or...

€298.80 *

Lipopeptide Pam-Dhc-SKKKK

Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or...

€211.31 *

Lipopeptide PamCSKKKK

Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or...

€211.31 *

No image available Lipopeptide SKKKK

Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or...

€172.15 *

Lipopeptide PamCGDPKHPKSF

Monoacylated lipopeptides, peptides with the unusual amino acid dihydroxypropylcystein (Dhc), or peptides representing the peptide moieties of Pam3Cys-SKKKK, Pam2Cys-SKKKK or...

€414.73 *

MALP-2-DI (Pam2CysGNNDESNISFKEKDI) -...

FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with...

€360.00 *

MALP-2-DI (Pam2CysGNNDESNISFKEKDI) -...

FSL-1 (Pam2CysGDPKHPKSF) showed higher activity than MALP-2 when tested for its capability to activate THP-1 cells to produce TNF-alpha and on HEK293 cells transfected with...

€360.00 *

Pam2Cys-SKKKK

Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on...

From €145.00 *

Pam2Cys-SKKKK-FLAG-tag

Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on...

From €225.00 *

Pam2Cys-SKKKK(Biot-Aca-Aca)-NH2

Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on...

From €225.00 *

Pam2Cys-SKKKK(Fluorescein-Aca-Aca)-NH2

Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on...

From €225.00 *

Pam2Cys-SKKKK(Rhodamine-Aca-Aca)-NH2

Toll-like receptors 2/6 heterodimers are activated by diacylated lipoproteins and their synthetic lipopeptide analogues. All offered diacylated lipopeptides are based on...

From €225.00 *

Pam3Cys-SKKKK

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

From €178.85 *

Pam3Cys-SKKKK (Aca-Aca-Biotin)

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

From €225.00 *

Pam3Cys-SKKKK (Fluorescein-Aca-Aca)

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

From €225.00 *

No image available Pam3Cys-SKKKK (Rhodamin-Aca-Aca)

Triacyl-Lipopeptid. The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and...

From €225.00 *

No image available Pam3Cys-SKKKK-FLAG-tag

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

From €225.00 *

Pam3CysAQEKEAKSELDYDQT

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

€618.76 *

Pam3CysGSHQMKSEGHANMQL

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

€618.76 *

Pam3CysKQNVSSLDEKNSVSV

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

€618.76 *

Pam3CysNNGGPELKSDEVAKS

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

€618.76 *

Pam3CysNNSGKDGNTSANSAD

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

€618.76 *

Pam3CysSQEPAAPAAEATPAG

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

€618.76 *

Pam3CysSSGNKSAPSSSASSS

The synthetic, triacylated lipopeptides represent the N-terminal lipohexadecapeptides, Pam3Cys-AA15, of bacterial lipoproteins. Names of lipoproteins and origin are indicated....

€618.76 *

   
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