rec. human Fibronectin

rec. human Fibronectin


Sipariş numarası: C6004.0020

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Fibronectin takes part in several cellular processes, including tissue repair, embryogenesis,... daha fazla
Ürün bilgileri "rec. human Fibronectin"

Fibronectin takes part in several cellular processes, including tissue repair, embryogenesis, blood clotting, and cell migration/adhesion.Plasma fibronectin level is elevated in severe coronary artery disease. Increased plasma fibronectin levels are related with venous thromboembolism (VTE) particularly in males, and extend the probable association between biomarkers and risk factors for arterial atherothrombosis and VTE. Fibronectin consists in 2 main forms: 1) as an insoluble glycoprotein dimer that serves as a linker in the etracellular matrix and 2) as a soluble disulphide linked dimer found in the plasma. The plasma form is produced by hepatocytes, and the ECM form is synthesized by fibroblasts, chondrocytes, endothelial cells, macrophages, as well as certain epithelial cells. Fibronectin alos takes part as a general cell adhesion molecule by anchoring cells to collagen or proteoglycan substrates. Fibronectin organizes cellular interaction with the ECM by binding to different components of the extracellular matrix and to membrane-bound Fibronectin receptors on cell surfaces.


Fibronectin Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 574 amino acids and having a molecular mass of 62.6kDa.

Biological activity:

Was measured by its ability to support cell attachment and spreading when used as a substratum for cell culture. The recommended concentration in this application for this effect is typically 1-5μg/cm2. Fibronectin can also be added to the media to support cell spreading at a concentration of 0.5-50μg/mL. Optimal concentrations will need to be determined for individual user applications.

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Specifications: Purity: >95% (by SEC, SDS-PAGE). Sterile filtered white lyophilized... daha fazla
 

Technische Daten:

Specifications:
Purity: >95% (by SEC, SDS-PAGE).

Sterile filtered white lyophilized (freeze-dried) powder. The lyophilized rHuPGH is soluble in water and most aqueous buffers above the isoelectric point (pI=7.8).

Quelle

Escherichia Coli.

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

eclass-Nr: 32-16-04-90
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