Recombinant Human IL-18 (rHuIL-18)

rec. human Interleukin-18 produced in E.Coli is a single, non-glycosylated polypeptide chain of 157 amino acids and a molecular mass of 18302 Dalton. IL-18 is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. The Sale of recombinant human IL-18 by Genaxxon is prohibited in the following countries: Unites States, Japan, United Kingdon, France, Spain, Italy, Germany, Austria, Belgium, Denmark, Portugal, Sweden, Switzerland, Liechtenstein, Australia, Taiwan and The Netherlands.