L-Methionine sulfoximine (MSX)

L-Methionine sulfoximine


Sipariş numarası: S2272.0001

Shipping: shipped at RT, stored at +2°C to +8°C
CAS-Nr: 15985-39-4

Teslim süresi yaklaşık. 5 iş günü

301,11 € *

Weight:

Please select the favoured pack size.

L-Methionine sulfoximine is a potent inhibitor of glutamine sythetase activity, that is widely... daha fazla
Ürün bilgileri "L-Methionine sulfoximine (MSX)"

L-Methionine sulfoximine is a potent inhibitor of glutamine sythetase activity, that is widely used as a selection agent for plasmid integration in Chinese hamster ovary (CHO) and other mammalian cell lines. The growing demand for high yield cell banks for production of recombinant proteins for therapeutics has resulted in two major systems for selection of stable and active clones, Methotrexate selection of dihydrofolate reductase (DHFR) overexpressing cells and MSX selection of glutamine synthetase overexpressing cells. Cells are grown in the absence of glutamine in the media and inhibition of the endogenous activity of glutamine synthease results in cell death for cells lacking overexpression. The MSX-glutamine synthase selection mechanism provides benefits over that of the Methotrexate-DHFR system in that it typically requires a single amplification step and results in significant reduction of time to produce high stability, highly amplified clones.

Methionine sulfoximine (MSX) increases ornithine decarboxylase activity, decreases the survival rate in a model of transient cerebral ischemia, and inhibits glutamine synthetase activity.

You will find further protease inhibitors here: Inhibitors >: Pepstatin A >, AEBSF >, Leupeptin >, TLCK >, PMSF >, Bestatine > or Diisopropylphosphorofluoridat (DFP) >.

İlgili bağlantılar "L-Methionine sulfoximine (MSX)"
Bizim üzerine yorumumuz "L-Methionine sulfoximine (MSX)"
Methionine sulfoximine (MSX) increases ornithine decarboxylase activity, decreases the survival rate in a model of transient cerebral ischemia, and inhibits glutamine synthetase activity.
Specifications: Assay: min. 95% (TLC) Appearance: white to off-white powder Solubility... daha fazla
 

Technische Daten:

Specifications:
Assay: min. 95% (TLC)
Appearance: white to off-white powder
Solubility (50mg/mL in H2O): clear to slightly hazy
a20°C/D (1% in 0.1 HCl): +10.8° - +14°
C5H12N2O3S
MW = 180.23 g/mol

Applikation:

selection agent for plasmid integration in Chinese hamster ovary (CHO) and other mammalian cell lines

Quelle

synthetic

Sicherheits Hinweise / Safety

H-Sätze: H315, H319, H335
GHS-Symbole: GHS07

Klassifizierungen / Classification

CAS-Nr: 15985-39-4
eclass-Nr: 32-16-04-90
Dokumente - Protokolle - Downloads daha fazla


Dokumente - Protokolle - Downloads

Hier finden Sie Informationen und weiterführende Literatur zu L-Methionine sulfoximine (MSX). Für weitere Dokumente (Zertifikate mit weiteren Lotnummern, Sicherheitsdatenblätter in anderer Sprache, weitere Produktinformationen) wenden Sie sich bitte an Genaxxon biosience unter: info@genaxxon.com oder Tel.: +49 731 3608 123.