Amphotericin B Powder
Sipariş numarası: M3108.0050
Shipping: Shipment: not cooled. Store at +2°C to +8°C. For laboratory usage only!CAS-Nr: 1397-89-3
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Fiyatlar artı KDV artı nakliye maliyetleri
For tissue culture to prevent growth of yeasts and fungi. Amphotericin B is an antifungal and was isolated from Streptomyces nodosus. It is one of the macrocyclic lactones and its action is fungistatic. Amphotericin B binds to sterols (eg. As cholesterol, cholestanol) with a planar structure and disturb thereby the permeability of the cell membrane, which it for ions (K+, Na+, H+) and other low molecular weight substances (eg. As amino acids, sugars, nucleotides ) permeable makes.
The cytotoxic concentration is 30μg/mL and the recommended work concentration at 2.5μg/mL.
Amphotericin B is almost insoluble in water at pH6-7, at pH2 and pH11 soluble with 100µg/mL. In DMSO 30-40mg/mL can be dissolved. Addition of deoxycholate in phosphate buffer improves water solubility.
Genaxxon bioscience offers a broad range of Antibiotics and Antimycotics as powder or solutions.
Fungizone is a registered trademark of E.R. Squibb.
Technische Daten:
Specifications:
Assay: >80%
Activity: min. 750 I.E./mg
Solubility: clear, yellow solution ((10%, DMF/1M HCl 3 : 1)
Solubility: almost unsoluble in water, soluble in DMSO
Amphotericin A: max. 15%
Water: max. 5%
C47H73NO17
MW = 924.08 g/mol
For tissue culture prepare a 2.5µg/mL solution.
Quelle
Streptomyces ssp.Sicherheits Hinweise / Safety
H-Sätze: H315, H319, H335GHS-Symbole: GHS07
R-Sätze: R22-37/38-41
Gefahrstoffkürzel: Xn
Klassifizierungen / Classification
EC-Nr: 215-742-2CAS-Nr: 1397-89-3
eclass-Nr: 32-19-90-90
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Referenzen..
Hier finden Sie Artikel und Literaturzitate, in denen die Autoren auf die hohe Qualität dieses Genaxxonprodukts vertrauen.
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PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control
Romy Walser, John E. Burke, Elena Gogvadze, Thomas Bohnacker, Xuxiao Zhang, Daniel Hess, Peter Küenzi, Michael Leitges, Emilio Hirsch, Roger L. Williams, Muriel Laffargue, Matthias P. Wymann
PLoS Biol. 2013 Jun; 11(6): e1001587. Published online 2013 Jun 25. doi: 10.1371/journal.pbio.1001587
PMCID: PMC3692425
