Amphotericin B Powder

Amphotericin B - chemical structure

Sipariş numarası: M3108.0050

Shipping: Shipment: not cooled. Store at +2°C to +8°C. For laboratory usage only!
CAS-Nr: 1397-89-3

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For tissue culture to prevent growth of yeasts and fungi. Amphotericin B is an antifungal... daha fazla
Ürün bilgileri "Amphotericin B Powder"

For tissue culture to prevent growth of yeasts and fungi. Amphotericin B is an antifungal and was isolated from Streptomyces nodosus. It is one of the macrocyclic lactones and its action is fungistatic. Amphotericin B binds to sterols (eg. As cholesterol, cholestanol) with a planar structure and disturb thereby the permeability of the cell membrane, which it for ions (K+, Na+, H+) and other low molecular weight substances (eg. As amino acids, sugars, nucleotides ) permeable makes.

The cytotoxic concentration is 30μg/mL and the recommended work concentration at 2.5μg/mL.

Amphotericin B is almost insoluble in water at pH6-7, at pH2 and pH11 soluble with 100µg/mL. In DMSO 30-40mg/mL can be dissolved. Addition of deoxycholate in phosphate buffer improves water solubility.

Genaxxon bioscience offers a broad range of Antibiotics and Antimycotics as powder or solutions.

Fungizone is a registered trademark of E.R. Squibb.

İlgili bağlantılar "Amphotericin B Powder"
Specifications: Assay: >80% Activity: min. 750 I.E./mg Solubility: clear, yellow solution... daha fazla

Technische Daten:

Assay: >80%
Activity: min. 750 I.E./mg
Solubility: clear, yellow solution ((10%, DMF/1M HCl 3 : 1)
Solubility: almost unsoluble in water, soluble in DMSO
Amphotericin A: max. 15%
Water: max. 5%
MW = 924.08 g/mol

For tissue culture prepare a 2.5µg/mL solution.


Streptomyces ssp.

Sicherheits Hinweise / Safety

H-Sätze: H315, H319, H335
GHS-Symbole: GHS07
R-Sätze: R22-37/38-41
Gefahrstoffkürzel: Xn

Klassifizierungen / Classification

EC-Nr: 215-742-2
CAS-Nr: 1397-89-3
eclass-Nr: 32-16-04-05
Dokumente - Protokolle - Downloads daha fazla

Dokumente - Protokolle - Downloads

Hier finden Sie Informationen und weiterführende Literatur zu Amphotericin B Powder. Für weitere Dokumente (Zertifikate mit weiteren Lotnummern, Sicherheitsdatenblätter in anderer Sprache, weitere Produktinformationen) wenden Sie sich bitte an Genaxxon biosience unter: oder Tel.: +49 731 3608 123.

Literatur .... daha fazla


Hier finden Sie Artikel und Literaturzitate, in denen die Autoren auf die hohe Qualität dieses Genaxxonprodukts vertrauen.
Listed below are articles and references, in which the authors trust in the high quality of this Genaxxon product.

Quelle/Source: NCBI PubMed >


PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control


Romy Walser, John E. Burke, Elena Gogvadze, Thomas Bohnacker, Xuxiao Zhang, Daniel Hess, Peter Küenzi, Michael Leitges, Emilio Hirsch, Roger L. Williams, Muriel Laffargue, Matthias P. Wymann


PLoS Biol. 2013 Jun; 11(6): e1001587. Published online 2013 Jun 25. doi: 10.1371/journal.pbio.1001587


PMCID: PMC3692425