Adenosine-3',5'-cyclic monophosphate sodium salt - cAMP
Sipariş numarası: M3442.0250
Shipping: shipped at RT, stored at -20°CCAS-Nr: 37839-81-9
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Adenosine-3′,5′-cyclic monophosphate (cAMP) is an activator of cyclic-AMP-dependent protein kinase A (PKA). The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis, eg. in resting human B-lymphocytes. Exogneous cAMP plays a role in the spontaneous activity and contraction of the heart muscle.
Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor.
References:
W Epstein.; LB Rothman-Denes. Adenosine 3': 5'-cyclic monophosphate as mediator of catabolite repression in Escherichia coli. PNAS.1975, 72, (6), 2300-2304.
CM Szego.; JS Davis. Adenosine 3', 5'-monophosphate in rat uterus: acute elevation by estrogen. PNAS.1967, 58, (4), 1711-1718.
Technische Daten:
Specifications:
Assay (HPLC): min. 98%
Appearance: white to off-white powder
Identity: determined by 31P- NMR, 1H-NMR, FAB-MS and UV
Solubility: 50mg/mL (H2O)
C10H11N5O6P x Na
MW = 351.19 g/mol
Quelle
syntheticSicherheits Hinweise / Safety
Klassifizierungen / Classification
CAS-Nr: 37839-81-9eclass-Nr: 32-16-05-02
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