Ova (257-264) SIINFEKL amide



Sipariş numarası: P3286.9505

Shipping: Shipment: not cooled. Store at -20°C. For laboratory usage only!
CAS-Nr: 138831-86-4 (free base)

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Ovalbumin (257-264) chicken has been used to trigger T cell activation in immunology studies.... daha fazla
Ürün bilgileri "Ova (257-264) SIINFEKL amide"

Ovalbumin (257-264) chicken has been used to trigger T cell activation in immunology studies.

T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are typically peptides between 8 and 11 amino acids in length and exhibiting MHC-specific sequence motifs. These antigenic peptides are derived from non-structural and structural proteins through proteolysis in the cytosolic compartment. Peptide-MHC-I complexes are then transported to the cell surface of antigen presenting cells and are recognised by CD8+ cytotoxic T lymphocytes (CTL). This interaction induces the differentiation of CTLs. Activated CTL lyse the infected cell, secrete cytokines, and proliferate. This mechanism ensures that cells infected by viruses or intracellular bacteria or cancer cells can be detected, since pathogen or cancer-specific MHC peptide complexes are displayed on the cell surface. CTL can recognise such abnormal cells and eliminate them. The genes of MHC I and II molecules are polymorphic. Each MHC allele has a distinct peptide binding motif which favours certain amino acid anchor residues at defined sequence positions.

İlgili bağlantılar "Ova (257-264) SIINFEKL amide"
Specifications: Purity: >95% (HPLC, 214 nm) Sequence: SIINFEKL-NH2 Sequence (three letter... daha fazla
 

Technische Daten:

Specifications:
Purity: >95% (HPLC, 214 nm)
Sequence: SIINFEKL-NH2
Sequence (three letter code): H - Ser - Ile - Ile - Asn - Phe - Glu - Lys - Leu - NH2
MW = 963.13 g/mol
C45H75N11O12 x C2HF3O2

Quelle

synthetic

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

CAS-Nr: 138831-86-4 (free base)
eclass-Nr: 32-16-04-09
Dokumente - Protokolle - Downloads daha fazla


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Hier finden Sie Informationen und weiterführende Literatur zu Ova (257-264) SIINFEKL amide. Für weitere Dokumente (Zertifikate mit weiteren Lotnummern, Sicherheitsdatenblätter in anderer Sprache, weitere Produktinformationen) wenden Sie sich bitte an Genaxxon biosience unter: info@genaxxon.com oder Tel.: +49 731 3608 123.

 
 
 
Literatur .... daha fazla

Referenzen..

Hier finden Sie Artikel und Literaturzitate, in denen die Autoren auf die hohe Qualität dieses Genaxxonprodukts vertrauen.
Listed below are articles and references, in which the authors trust in the high quality of this Genaxxon product.

Quelle/Source: NCBI PubMed >

 

Vaccination with an Adenoviral Vector That Encodes and Displays a Retroviral Antigen Induces Improved Neutralizing Antibody and CD4+ T-Cell Responses and Confers Enhanced Protection

 

Wibke Bayer, Matthias Tenbusch, Ruth Lietz, Lena Johrden, Simone Schimmer, Klaus Überla, Ulf Dittmer, Oliver Wildner

 

J Virol. 2010 Feb; 84(4): 1967–1976.  Published online 2009 Dec 9. doi: 10.1128/JVI.01840-09

 

PMCID: PMC2812386

Coexpression of GM-CSF and antigen in DNA prime-adenoviral vector boost immunization enhances polyfunctional CD8+ T cell responses, whereas expression of GM-CSF antigen fusion protein induces autoimmunity

Matthias Tenbusch, Seraphin Kuate, Bettina Tippler, Nicole Gerlach, Simone Schimmer, Ulf Dittmer, Klaus Überla

BMC Immunol. 2008; 9: 13.  Published online 2008 Apr 11. doi: 10.1186/1471-2172-9-13

PMCID: PMC2324072

 

 
 
 
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