SARS-CoV-2 (COVID-19) Nucleocapsidprotein - (1-419), His-Tag

Beneath the envelope membrane, the coronavirus SARS-CoV-2 shows an icosahedral nucleocapsid that contains the genetic information in form of positive sensed single-stranded RNA. RNA and a phosphorylated nucleocapsid protein do form a protein-RNA complex. The phosphoprotein is necessary to keep the capsid in its helical structure acting as a RNA chaperone packing the RNA into the viral capsid.

Together with the matrix (M) protein, the N-protein is one of the most abundant proteins in the virus. The N-protein is important for viral replication and seems to modulate cellular signaling, too. It has a very conserved sequence that is highly immunogenic.