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Vitronectin is a multifunctional glycoprotein present in blood and in the extra-cellular matrix. It is an important participant in a large variety of biological functions. These include cell attachment, spreading, migration, blood coagulation, plasminogen activation, fibrinolysis, and the regulation of complement function.
Recombinant human vitronectin (rhnVN) from Genaxxon is a recombinant human protein that provides a defined surface for feeder-free culture of all sorts of cells including pluripotent stem cells (PSCs). When used with the appropriate chemical defined serum-free medium vitronectin has been proven to maintain pluripotency and normal growth characteristics in multiple PSC lines.
rHu VN is of defined composition avoiding the lot to lot variability of plasma derived VN or extracts of EHS tumor tissue. It is produced from stable HEK cells capable of post-translational modfication (PTM) and processing which are conferring the protein superior quality regarding biologic activity and protein stability.
Due to recombinant production upscaling is possible enabling large yields.
The complete open reading frame of Vitronection encodes for 459 amino acids which are preceded by a 19 amino acid signal peptide. It contains three glycosilation sites and its carbohydrate moiety contributes about 30% to this molecular mass.
Reduce Variability rHu Vitronectin is a defined, recombinant human protein that reduces variability in PSC cultures compared to human-plasma derived vitronectin and standard basement membrane extracts (BMEs).
Purity: >95% (SDS-PAGE)
Identity: tested with polyclonal antibodies
Activity: tested in cell attachment and spreading assay
MW=65 kDa (monomer)
For use in cell culture applications, especially of human pluripotent stem cells (PSCs).
Applikation:stem cell culture
Sicherheits Hinweise / Safety
Klassifizierungen / Classificationeclass-Nr: 32-16-04-09
Dokumente - Protokolle - Downloads
Hier finden Sie Informationen und weiterführende Literatur zu rHu Vitronectin. Für weitere Dokumente (Zertifikate mit weiteren Lotnummern, Sicherheitsdatenblätter in anderer Sprache, weitere Produktinformationen) wenden Sie sich bitte an Genaxxon biosience unter: email@example.com oder Tel.: +49 731 3608 123.