rHu HER2-ECD / ErbB2/Her2

rHu HER2-ECD / ErbB2/Her2

Sipariş numarası: S5557.0100

Shipping: shipped on wet ice, store at -20°C

Teslim süresi yaklaşık. 5 iş günü

618,33 € *


Please select the favoured pack size.

HER2/neu/ErbB-2 (human epidermal growth factor receptor 2) is a membrane glycoprotein of the... daha fazla
Ürün bilgileri "rHu HER2-ECD / ErbB2/Her2"

HER2/neu/ErbB-2 (human epidermal growth factor receptor 2) is a membrane glycoprotein of the ErbB family of tyrosine kinase receptors. This protein family members (ErbB1-4) serve as receptors for epidermal growth factor. ErbB2 is found on the on the surface of epithelial cells and strongly overexpressed on the membrane of cancer cells especially breast cancer cells. ErbB2 has no identified ligand but rather forms heterodimers with one the other ErbB receptors. These complexes are of high affinity to its ligands. By binding of the ligand a conformational change of the cytoplasmatic tyrosine kinase part of the ErbB2 receptor results in phosphorylation of the initial PI3K/Akt signal transduction cascade protein and effects cell proliferation. Human ErbB2 consists of 1255 amino acids (aa) with a 21 aa leader sequence, a 631 aa extracellular domain (ED), a 23 aa transmembrane region, and a 580 aa cytoplasmatic domain. The soluble ED can be shed proteolytically from the cell surface, is strongly glycosylated and of a MW of 95-105 kDa.


İlgili bağlantılar "rHu HER2-ECD / ErbB2/Her2"
Specifications: Purity: >95% (SDS-PAGE)  MW: 95-105 kDa band, partly di- and trimeric... daha fazla

Technische Daten:

Purity: >95% (SDS-PAGE) 
MW: 95-105 kDa band, partly di- and trimeric forms
1µg/µL solution
Identity: tested with polyclonal antibodies
Activity: tested in functional and cell adhesion assays


HEK293 cells

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

eclass-Nr: 32-16-04-09
Dokumente - Protokolle - Downloads daha fazla

Dokumente - Protokolle - Downloads

Hier finden Sie Informationen und weiterführende Literatur zu rHu HER2-ECD / ErbB2/Her2. Für weitere Dokumente (Zertifikate mit weiteren Lotnummern, Sicherheitsdatenblätter in anderer Sprache, weitere Produktinformationen) wenden Sie sich bitte an Genaxxon biosience unter: info@genaxxon.com oder Tel.: +49 731 3608 123.