MicroRNAs play a pivotal role in shaping cell phenotype. However, until recently, there were no effective methods to observe miRNA expression within an individual cell, within complex animal tissues, without introducing technical and/or biological artefacts.
The human body is colonized by microorganisms of diverse phylogenetic origins, principally bacteria, archaea, eukaryote, and viruses. In health, specific microbes exist in a symbiotic relationship with their human host, where they contribute essential vitamins and nutrients, prime the human immune system to recognize “non-self” antigens, and produce useful anti-inflammatory compounds that deter disease-causing microbes.
Non-protein-coding RNAs (ncRNAs) are expressed in viruses, archaea, prokaryotes and eukaryotes. They fulfil vital roles in the regulation of chromatin architecture, epigenetic memory, transcription, RNA splicing, editing and turnover. To date, at least 18 distinct types of ncRNA have been identified, which are classified according to their size, function, subcellular localization and target specificity.
Here, we focus on two approaches to the safe and efficient design and delivery of CRISPR/Cas9 gene editing technology.
The development of novel antibacterial drugs, such as synthetic venom antimicrobial peptides (AMPs), is a positive step towards overcoming antimicrobial drug resistance.
To date, several different CRISPR/Cas systems have been isolated and classified according to their molecular structure, substrate specificity and the conditions that support their optimum activity.
Priavoid, a company based in Jülich (Germany), has successfully completed a Phase I project with peptides consisting of D-amino acids instead of the natural occuring L-configuration.
In the articles below you will find the authors already relying on the Genaxxon products. We say thank you to these authors, trusting in our service. Let us convince you as well.
Chinese scientists have succeeded in changing the genetic material of pigs so that they are resistant to the CSF virus. A combination of the CRISPR / Cas9 method and the RNA interference (RNAi) technology was used.
Dog`s and cat`s allergy and exclusion diets are often contaminated with foreign proteins and fats. Small amounts of a potential allergen (such as protein of a certain species) in feed are often sufficient to trigger allergic reactions.
Cell-penetrating peptides (CPPs), also known as protein transduction domains (PTDs), are typically 5-30 amino acid residues in length. Whether they occur naturally or are synthetic, CPPs are designed to breach cell membranes and deliver bioactive cargo to the intracellular space.
Wine production, while considered an art form, owes an increasing debt to the latest molecular genetic technologies. Not only do these facilitate batch-to-batch consistency, they also enable the generation of novel strains of grape microflora. While the choice of grapes is important, so too is the interplay between extrinsic and intrinsic factors, and the technological decisions made at every step in the process. Together, these determine whether the finished product will be classed as a “vintage wine”, a “quaffing wine”, or “vinegar”.
1 From 3