Vorteile im Überblick
- Purity: >95% (HPLC)
- Sequence: VMAPRTLIL
- HLA-B*08:01
PREISE
| Anzahl | Stückpreis |
|---|---|
| Bis 2 |
169,00 €
|
| Ab 3 |
126,75 €
169,00 €
(25% gespart)
|
Lieferzeit 3–8 Tage
Produktnummer:
P2670.9501
Lieferzeit:
2-5 Tage
Unsere Vorteile
- Kostenloser Versand
- Versand innerhalb von 24h
- 30 Tage Geld-Zurück-Garantie
- Bequemer Kauf auf Rechnung
Für genaue Informationen zum Liefertermin wenden Sie sich bitte an Genaxxon.
Produktinformationen "HCMV UL40 15-23 (HLA-E) - VMAPRTLIL"
HCMV UL40 15-23 acts as an important negative regulator of natural killer cell activity. For this the HCMV UL40 15-23 peptide (epitope ID69921) is often used as positive control.
HCMV UL40 15-23 is part of the immune evasion strategie of the Human Cytomegalovirus (HCMV). The virus downregulates HLA class Ia molecule expression in order to evade T cell recognition. However, a lack of surface HLA class Ia molecules triggers cytotoxicity of Natural Killer (NK) cells. To counteract this effect, the Cytomegalovirus promotes upregulation of HLA-E and provides the peptide HCMV UL40 15-23 (VMAPRTLIL), which is identical with the leader sequence of HLA-Cw03 (VMAPRTLIL). When loaded onto HLA-E, this peptide conferres resistance to NK cell lysis via the CD94/NKG2A receptor.
HLA-E is presenting peptides derived from self-proteomic content and peptides of pathogenic origin.
VMAPRTLIL is part of the following proteins of human origin:
- Major histocompatibility complex, class I, C (UniProt:A0A140T9M0, A0A140T9U0, A0A0G2JH50, A0A140T912 and A0A140T9Z4)
- HLA class I histocompatibility antigen C alpha chain (UniProt:Q53YP1, Q5RIP0)
- HLA class I antigen (UniProt:Q5QT33)
- Isoform 2 of HLA class I histocompatibility antigen, C alpha chain (UniProt:P10321-2)
- Major histocompatibility complex, class I, C (UniProt:A0A140T9M0, A0A140T9U0, A0A0G2JH50, A0A140T912 and A0A140T9Z4)
- HLA class I histocompatibility antigen C alpha chain (UniProt:Q53YP1, Q5RIP0)
- HLA class I antigen (UniProt:Q5QT33)
- Isoform 2 of HLA class I histocompatibility antigen, C alpha chain (UniProt:P10321-2)
Specifications:
Purity: >95% (HPLC)
Sequence: VMAPRTLIL
HLA-B*08:01
Lyophilized white powder
Dokumente - Protokolle - Downloads :
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