PLP (139-151) - HCLGKWLGHPDKF

PLP (139-151) - HCLGKWLGHPDKF


Order number: P2273.9505

Shipping: shipped at RT, store at -20°C

Delivery time: 3- 8 working days
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From 3 €181.02 *

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PLP (139 - 151) - HCLGKWLGHPDKF represents a short peptide sequence of the protein lipid part of... more
Product information "PLP (139-151) - HCLGKWLGHPDKF"

PLP (139 - 151) - HCLGKWLGHPDKF represents a short peptide sequence of the protein lipid part of the myelin sheath. Such proteins are obviously targets of the immune defense in multiple sclerosis.

Multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS), is characterised by primary demyelination. It is widely thought that this is the result of an autoimmune attack against myelin components. Potential target antigens in MS are proteins of the myelin sheath such as myelin oligodendrocyte glycoprotein (MOG), myelin basic protein (MBP), and proteolipid protein (PLP). Experimental autoimmune encephalomyelitis (EAE) has proven to be a particularly useful animal model. T cell epitopes of MOG for the induction of EAE in mice have been identified. Several inhibitors of amyloid-beta aggregation have been published. Many of them are fragments and modified peptides derived from the native amyloid-beta sequence. Others were identified by phage display approaches. An overview about peptides that target amyloid-beta is described by Stains et al. (2007) ChemMedChem 2, 1674-1692.

More products around "PLP (139-151) - HCLGKWLGHPDKF"
Specifications: Purity: >95% (HPLC, 214nm) Sequence: HCLGKWLGHPDKF Appearance: lyophilized... more
 

Technical Data:

Specifications:
Purity: >95% (HPLC, 214nm)
Sequence: HCLGKWLGHPDKF
Appearance: lyophilized white powder

Source

synthetic

Sicherheits Hinweise / Safety

Klassifizierungen / Classification

eclass-Nr: 34-16-04-90
Dokumente - Protokolle - Downloads more

Dokumente - Protokolle - Downloads

Here you will find information and further literature on PLP (139-151) - HCLGKWLGHPDKF. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.

 
 
 
Literatur .... more

Referenzen..

Hier finden Sie Artikel und Literaturzitate, in denen die Autoren auf die hohe Qualität dieses Genaxxonprodukts vertrauen.
Listed below are articles and references, in which the authors trust in the high quality of this Genaxxon product.

Quelle/Source: NCBI PubMed >

Nutritional control of IL-23/Th17-mediated autoimmune disease through HO-1/STAT3 activation

Jürgen Brück, Julia Holstein, Ivana Glocova, Ursula Seidel, Julia Geisel, Toshio Kanno, Jin Kumagai, Naoko Mato, Stephan Sudowe, Katja Widmaier, Tobias Sinnberg, Amir S. Yazdi, Franziska C. Eberle, Kiyoshi Hirahara, Toshinori Nakayama, Martin Röcken, Kamran Ghoreschi

Sci Rep. 2017; 7: 44482.  Published online 2017 Mar 14. doi: 10.1038/srep44482

PMCID: PMC5349589