MHC-I and MHC-II Peptides

Genaxxon bioscience offers different peptides for examination on binding studies of MHC-Class-I and MHC-Class-II complexes. Examples for possible applications are: T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response.

Synonyms for the MHC proteins are: MHC; Mbp-2 protein; Mhc-binding protein 2; Major histocompatibility complex-binding protein 2; Ribonucleic acid formation factor MBP 2 (human reduced;148770-78-9; Major Histocompatibility Complex; Histocompatibility Complex; CID447329. For studies of the role of these complexes Genaxxon bioscience offers peptides with a defined and known amino acid sequence and high purity, which enables an exact interpretation of results, without ambiguity that might be caused by impurities.

Examples of these peptides are LCMV GP (33-41) KAVYNFATM), LCMV GP70 (70-77) (GVYQFKSV), Myelopeptide-1 (FLGFPT), NY-ESO-1 (158-180) (LLMWITQCFLPVFLAQPPSGQRR), Melan-A/MART-1 (26-35) (EAAGIGILTV), Mage-3 (FLWGPRALV), Influenza A NP (366-374) (ASNENMETM), (Met 210) Melanoctye Protein PMEL 17 (209-217) (human) (IMDQVPFSV), SMD1 (83-119) (VEPKVKSKKREAVAGRGRGRGRGRGRGRGRGRGGPRR), CLIP (85-99) (KPVSQMRMATPLLMR) or PADRE Peptide (AKFVAAWTLKAAA).

MHC molecules (MHC = major histocompatibility complex) are proteins with the major function to bind protein fragments (peptides) and to present them on the cell surface to the immune system of the organism (vertebrates) for recognition by the appropriate T-cells, thus enabling the immune system to react and to kill infected cells by cytotoxic T-lymphocytes or to activate B-cells.

MHC proteins are Glycoproteins bound to the cell membrane of vertebrates. Dependend on the specific species other terms/notations are used. In humans, the MHC is also called the human leukocyte antigen > (HLA). MHC molecules mediate interactions of leukocytes, with other leukocytes or with body cells. The MHC determines compatibility of donors for organ transplant, as well as one's susceptibility to an autoimmune disease via crossreacting immunization.

There are two classes of MHC complexes that interact with the immune system and which differ structurally and in their function. While MHC-Class-I complexes are located on most cells of an organism, MHC-Class-II complexes can only be found on few cell types, like B-Cells, Macrophages, dendritic cells or thymic epitheliall cells.

MHC-I

MHC I occurs as a chain composed of three domains—a1, a2, and a3 and a b-chain a non-MHC molecule. The a3 domain is transmembrane, anchoring the MHC-class-I molecule to the cell membrane. The protein region inbetween domain a1 and a2 forms a peptide binding groove that represents a highly variable amino acid region that can bind millions of different peptides comparable to antibodies.

MHC-Class-I molecules bind peptides generated mainly from degradation of cytosolic proteins by the proteasome > presenting them afterwards to the immune system. The peptide is bound to the extracellular part of the class I MHC molecule. Thus, the function of the MHC-Class-I is to display intracellular proteins to cytotoxic T cells > (CTLs). However, MHC-Class-I can also present peptides generated from exogenous proteins, in a process known as cross-presentation >.

A normal cell will display peptides from normal cellular protein turnover on its MHC-Class-I, and CTLs will not be activated in response to them due to central and peripheral tolerance mechanisms. When a cell expresses foreign proteins, such as after viral infection, a fraction of the MHC-Class-I will display these peptides on the cell surface. Consequently, CTLs specific for the MHC:peptide complex will recognize and kill the presenting cell.

A normal cell contains about 105-106 MHC-Class-I moleculres, which are able to recognize about 104 different peptides with individual copy numbers between 1 and 10,000. The immune system is tolerant against "self" peptides. In case of an infection of a cell, new "non-self" peptides will be presented by the MHC-Class-I complexes, which will be recognized by CD8+-cells as external. Besides their function to combat virus infected or tumor cells, T-cells, which recognize peptides presented by MHC-Class-I will also be responsible to remove parasites or cells infected by bacteria.

MHC-II

MHC class II is formed of two chains, α and β, of almost identical size, each having two domains - α1 and α2 and β1 and β2 - each chain having a transmembrane domain, α2 and β2, respectively, anchoring the MHC class II molecule to the cell membrane. The highly variable peptide-binding groove is formed of the heterodimer of α1 and β1.

In contrary to the MHC-Class-I complex, MHC-Class-II molecules will present extracellular proteins, which entered the cell e.g. by receptor mediated endocytosis, unspecific macropinocytosis or phagocytosis.

During synthesis of MHC-Class-II molecules in the endoplasmic reticulum, the α and β chains are produced and complexed with a special polypeptide known as the invariant chain. The nascent MHC-Class-II protein in the rough ER has its peptide-binding groove blocked by the invariant chain to prevent it from binding cellular peptides or peptides from the endogenous pathway (such as those that would be loaded onto MHC-Class-I proteins.

The invariant chain also facilitates the export of MHC-Class-II from the ER to the golgi, followed by fusion with a late endosome containing endocytosed, degraded proteins. The invariant chain is then broken down in stages by proteases called cathepsins >, leaving only a small fragment known as CLIP > which maintains blockage of the peptide binding groove on the MHC molecule.

Genaxxon bioscience offers different peptides for examination on binding studies of MHC-Class-I and MHC-Class-II complexes. Examples for possible applications are: T-cell assays, Immune... read more »
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MHC-I and MHC-II Peptides

Genaxxon bioscience offers different peptides for examination on binding studies of MHC-Class-I and MHC-Class-II complexes. Examples for possible applications are: T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response.

Synonyms for the MHC proteins are: MHC; Mbp-2 protein; Mhc-binding protein 2; Major histocompatibility complex-binding protein 2; Ribonucleic acid formation factor MBP 2 (human reduced;148770-78-9; Major Histocompatibility Complex; Histocompatibility Complex; CID447329. For studies of the role of these complexes Genaxxon bioscience offers peptides with a defined and known amino acid sequence and high purity, which enables an exact interpretation of results, without ambiguity that might be caused by impurities.

Examples of these peptides are LCMV GP (33-41) KAVYNFATM), LCMV GP70 (70-77) (GVYQFKSV), Myelopeptide-1 (FLGFPT), NY-ESO-1 (158-180) (LLMWITQCFLPVFLAQPPSGQRR), Melan-A/MART-1 (26-35) (EAAGIGILTV), Mage-3 (FLWGPRALV), Influenza A NP (366-374) (ASNENMETM), (Met 210) Melanoctye Protein PMEL 17 (209-217) (human) (IMDQVPFSV), SMD1 (83-119) (VEPKVKSKKREAVAGRGRGRGRGRGRGRGRGRGGPRR), CLIP (85-99) (KPVSQMRMATPLLMR) or PADRE Peptide (AKFVAAWTLKAAA).

MHC molecules (MHC = major histocompatibility complex) are proteins with the major function to bind protein fragments (peptides) and to present them on the cell surface to the immune system of the organism (vertebrates) for recognition by the appropriate T-cells, thus enabling the immune system to react and to kill infected cells by cytotoxic T-lymphocytes or to activate B-cells.

MHC proteins are Glycoproteins bound to the cell membrane of vertebrates. Dependend on the specific species other terms/notations are used. In humans, the MHC is also called the human leukocyte antigen > (HLA). MHC molecules mediate interactions of leukocytes, with other leukocytes or with body cells. The MHC determines compatibility of donors for organ transplant, as well as one's susceptibility to an autoimmune disease via crossreacting immunization.

There are two classes of MHC complexes that interact with the immune system and which differ structurally and in their function. While MHC-Class-I complexes are located on most cells of an organism, MHC-Class-II complexes can only be found on few cell types, like B-Cells, Macrophages, dendritic cells or thymic epitheliall cells.

MHC-I

MHC I occurs as a chain composed of three domains—a1, a2, and a3 and a b-chain a non-MHC molecule. The a3 domain is transmembrane, anchoring the MHC-class-I molecule to the cell membrane. The protein region inbetween domain a1 and a2 forms a peptide binding groove that represents a highly variable amino acid region that can bind millions of different peptides comparable to antibodies.

MHC-Class-I molecules bind peptides generated mainly from degradation of cytosolic proteins by the proteasome > presenting them afterwards to the immune system. The peptide is bound to the extracellular part of the class I MHC molecule. Thus, the function of the MHC-Class-I is to display intracellular proteins to cytotoxic T cells > (CTLs). However, MHC-Class-I can also present peptides generated from exogenous proteins, in a process known as cross-presentation >.

A normal cell will display peptides from normal cellular protein turnover on its MHC-Class-I, and CTLs will not be activated in response to them due to central and peripheral tolerance mechanisms. When a cell expresses foreign proteins, such as after viral infection, a fraction of the MHC-Class-I will display these peptides on the cell surface. Consequently, CTLs specific for the MHC:peptide complex will recognize and kill the presenting cell.

A normal cell contains about 105-106 MHC-Class-I moleculres, which are able to recognize about 104 different peptides with individual copy numbers between 1 and 10,000. The immune system is tolerant against "self" peptides. In case of an infection of a cell, new "non-self" peptides will be presented by the MHC-Class-I complexes, which will be recognized by CD8+-cells as external. Besides their function to combat virus infected or tumor cells, T-cells, which recognize peptides presented by MHC-Class-I will also be responsible to remove parasites or cells infected by bacteria.

MHC-II

MHC class II is formed of two chains, α and β, of almost identical size, each having two domains - α1 and α2 and β1 and β2 - each chain having a transmembrane domain, α2 and β2, respectively, anchoring the MHC class II molecule to the cell membrane. The highly variable peptide-binding groove is formed of the heterodimer of α1 and β1.

In contrary to the MHC-Class-I complex, MHC-Class-II molecules will present extracellular proteins, which entered the cell e.g. by receptor mediated endocytosis, unspecific macropinocytosis or phagocytosis.

During synthesis of MHC-Class-II molecules in the endoplasmic reticulum, the α and β chains are produced and complexed with a special polypeptide known as the invariant chain. The nascent MHC-Class-II protein in the rough ER has its peptide-binding groove blocked by the invariant chain to prevent it from binding cellular peptides or peptides from the endogenous pathway (such as those that would be loaded onto MHC-Class-I proteins.

The invariant chain also facilitates the export of MHC-Class-II from the ER to the golgi, followed by fusion with a late endosome containing endocytosed, degraded proteins. The invariant chain is then broken down in stages by proteases called cathepsins >, leaving only a small fragment known as CLIP > which maintains blockage of the peptide binding groove on the MHC molecule.

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CMV IE-1 (316-324) (I1) HLA-A*02:01 ILEETSVML
CMV IE-1 (316-324) (I1) HLA-A*02:01 ILEETSVML
Antigen peptide IE (316-324) (I1) HLA-A*02:01 (ILEETSVML) for stimulation of antigen-specific T cells in T cell assay such as ELISPOT, ICS, cytotoxicity or proliferation assays. ILEETSVML has an amino acid substitution at position 316...
From €85.50 * €90.00 *
CMV IE-1 (316-324) HLA-A*0201 VLEETSVML
CMV IE-1 (316-324) HLA-A*0201 VLEETSVML
CMV IE-1 (316-324) HLA-A * 0201 VLEETSVML for stimulation of T cells. The peptide was synthesized as presented by MHC class I molecules. IE-1 stands for immediate-early protein 1. CMV stands for human cytomegealovirus, or HCMV for human...
From €85.50 * €90.00 *
CMV IE-1 (99-107) RIKEHMLKK
CMV IE-1 (99-107) RIKEHMLKK
CMV IE-1 (316-324) HLA-A*02:01 VLEETSVML for the stimulation of T cells. The peptide is synthesized as presented by the MHC class system. IE-1 stands for immediate-early protein 1. CMV for human cytomegealovirus, or HCMV for human...
From €85.50 * €90.00 *
CMV Peptide Library Pool
CMV Peptide Library Pool
CMV peptide pool consisting of 14 different CMV peptides each corresponding to a defined HLA class I-restricted T cell epitope from cytomegalovirus (CMV). The peptides of this product are supplied as lyophilized trifluoracetate salts....
€55.00 *
CMV pp50 (245-253) HLA-A*01:01 VTEHDTLLY
CMV pp50 (245-253) HLA-A*01:01 VTEHDTLLY
CMV pp50 (245-253) HLA-A*01:01 VTEHDTLLY zur Stimulation von T-Zellen. Das Peptid wurde so synthetisiert, wie es von MHC-Klasse-I-Molekülen präsentiert wird.
From €85.50 * €90.00 *
CMV pp65 (16-24) HLA-A*11:01 GPISGHVLK
CMV pp65 (16-24) HLA-A*11:01 GPISGHVLK
CMV pp65 (16-24) HLA-A*11:01 GPISGHVLK for stimulation of T cells. The peptide was synthesized as presented by MHC class I molecules. CMV stands for human cytomegalovirus, or HCMV for human cytomegalovirus or HPV human herpesvirus.
From €85.50 * €90.00 *
CMV pp65 (417-426) HLA-B*07:02 TPRVTGGGAM
CMV pp65 (417-426) HLA-B*07:02 TPRVTGGGAM
CMV pp65 (417-426) HLA-B * 07: 02 TPRVTGGGAM for stimulation of T cells. The peptide was synthesized as presented by MHC class I molecules. CMV stands for human cytomegalovirus, or HCMV for human cytomegalovirus or HPV human herpesvirus.
From €85.50 * €90.00 *
CMV pp65 (417-426), amid HLA-B*07:02 TPRVTGGGAM-NH2
CMV pp65 (417-426), amid HLA-B*07:02...
CMV pp65 (417-426) HLA-B * 07: 02 TPRVTGGGAM for stimulation of T cells. The peptide was synthesized as presented by MHC class I molecules. CMV stands for human cytomegalovirus, or HCMV for human cytomegalovirus or HPV human herpesvirus.
From €85.50 * €90.00 *
CMV pp65 (495-503) HLA-A*02:01 NLVPMVATV
CMV pp65 (495-503) HLA-A*02:01 NLVPMVATV
Single peptide (NLVPMVATV) for stimulation of human CMV specific CD8+ T-cells. The peptide is synthesised as it is presented by the MHC class I HLA-A*0201 allele. Purities offered: >95%. T-cell epitopes are presented on the surface of...
€153.83 *
CMV pp65 Peptide Pool
CMV pp65 Peptide Pool
CMV pp65 Control Pool of 138 peptides derived from a peptide scan (15mers with 11 aa overlap) through 65 kDa phosphoprotein (pp65) (UniProtKB - P06725) of Human cytomegalovirus (HHV-5) frequently used as positive control. Length 65 kDa...
€210.00 *
EBNA-1 Protein (562-570) FMVFLQTHI
EBNA-1 Protein (562-570) FMVFLQTHI
The Epstein-Barr virus (EBV), also called Human herpes virus 4 (HHV-4), is a virus of the herpes family (which includes Herpes simplex virus and Cytomegalo virus). On infecting the B-lymphocyte, the linear virus genome circularizes and...
From €85.50 * €90.00 *
EBV BMLF-1 280-288 (HLA-A*02:01) GLCTLVAML
EBV BMLF-1 280-288 (HLA-A*02:01) GLCTLVAML
Single peptide (GLCTLVAML) for stimulation of humanEBV BMLF-1(280-288) CD8+ specific CD8+ T-cells. The peptide is synthesised as it is presented by the MHC class I HLA-A*0201 allele. Purities offered: >95%. T-cell epitopes are presented...
From €88.07 * €90.00 *
EBV BMRF1 (208-216) HLA-A*02:01 TLDYKPLSV
EBV BMRF1 (208-216) HLA-A*02:01 TLDYKPLSV
The Epstein–Barr virus (EBV), formally called Human gammaherpesvirus 4, is one of eight known human herpesvirus types in the herpes family, and is one of the most common viruses in humans.
From €85.50 * €90.00 *
EBV EBNA-1 (407-417) HLA-B*35:01 HPVGEADYFEY
EBV EBNA-1 (407-417) HLA-B*35:01 HPVGEADYFEY
From €85.50 * €90.00 *
EBV EBNA-3A (325-333) HLA-B*08:01 FLRGRAYGL
EBV EBNA-3A (325-333) HLA-B*08:01 FLRGRAYGL
From €85.50 * €90.00 *
EBV EBNA-3A (379-387) HLA-B*07:02 RPPIFIRRL
EBV EBNA-3A (379-387) HLA-B*07:02 RPPIFIRRL
Single peptide (RPPIFIRRL) for stimulation of human EBV EBNA-3A (379-387) specific CD8+ T-cells. The peptide is synthesised as it is presented by the MHC class I HLA-B*0702 allele. T-cell epitopes are presented on the surface of...
From €85.50 * €90.00 *
EBV LMP-2 (419-427) HLA-A*24:02 TYGPVFMCL
EBV LMP-2 (419-427) HLA-A*24:02 TYGPVFMCL
From €85.50 * €90.00 *
EBV LMP2 (131-139) HLA-A*24:02 PYLFWLAAI
EBV LMP2 (131-139) HLA-A*24:02 PYLFWLAAI
From €85.50 * €90.00 *
gp100 (154-162) HLA-A*02:01 KTWGQYWQV
gp100 (154-162) HLA-A*02:01 KTWGQYWQV
gp100 (154-162) HLA-A*02:01 KTWGQYWQV is a linear peptidic epitope (epitope ID 33915) studied as part of Melanocyte protein PMEL from Homo sapiens (human). This epitope has been studied for immune reactivity, tested in T cell assays, B...
From €85.50 * €90.00 *
gp100 (280-288) HLA-A*02:01 YLEPGPVTA
gp100 (280-288) HLA-A*02:01 YLEPGPVTA
From €85.50 * €90.00 *
HBV core (117-125) (HLA-A*24:02) - EYLVSFGVW
HBV core (117-125) (HLA-A*24:02) - EYLVSFGVW
HBV envelope (183-191) (HLA-A*02:01) - FLLTRILTI is a linear peptidic epitope (epitope ID16755) studied as part of Large envelope protein from Hepatitis B virus. This epitope has been studied for immune reactivity. Tested in T cell...
From €85.50 * €90.00 *
HBV core (18-27) (HLA-A*02:01) - FLPSDFFPSV
HBV core (18-27) (HLA-A*02:01) - FLPSDFFPSV
HBV core (18-27) (HLA-A*02:01) - FLPSDFFPSV is a linear peptidic epitope studied as part of Capsid protein from Hepatitis B virus and External core antigen from Hepatitis B virus. HBV core peptide FLPSDFFPSV (HLA-A*02:01) for stimulation...
From €85.50 * €90.00 *
HBV core (18-27) (subtype ADR4) (HLA-A*02:01) - FLPSDFFPSI
HBV core (18-27) (subtype ADR4) (HLA-A*02:01) -...
HBV core (18-27) (subtype ADR4) (HLA-A*02:01) - FLPSDFFPSI is a linear peptidic epitope (epitope ID16832) studied as part of External core antigen from Hepatitis B virus and Capsid protein from Hepatitis B virus. This epitope has been...
From €85.50 * €90.00 *
HBV core (19-27) (HLA-B*35:01) (HLA-B*51:01) - LPSDFFPSV
HBV core (19-27) (HLA-B*35:01) (HLA-B*51:01) -...
HBV core (19-27) (HLA-B*35:01) (HLA-B*51:01) LPSDFFPSV is a linear peptidic epitope (epitope ID38701) studied as part of Large envelope protein from Hepatitis B virus. This epitope has been studied for immune reactivity. Tested in T cell...
From €85.50 * €90.00 *
HBV core antigen (88-96) (HLA-A*11:01) - YVNVNMGLK
HBV core antigen (88-96) (HLA-A*11:01) - YVNVNMGLK
HBV core antigen (88-96) (HLA-A*11:01) YVNVNMGLK is a linear peptidic epitope (epitope ID76370) studied as part of Capsid protein from Hepatitis B virus and External core antigen from Hepatitis B virus. This epitope has been studied for...
From €85.50 * €90.00 *
HBV envelope (183-191) (HLA-A*02:01) - FLLTRILTI
HBV envelope (183-191) (HLA-A*02:01) - FLLTRILTI
HBV envelope (183-191) (HLA-A*02:01) - FLLTRILTI is a linear peptidic epitope (epitope ID16755) studied as part of Large envelope protein from Hepatitis B virus. This epitope has been studied for immune reactivity. Tested in T cell...
From €85.50 * €90.00 *
HBV envelope (348-357) (HLA-A*02:01) - GLSPTVWLSV
HBV envelope (348-357) (HLA-A*02:01) - GLSPTVWLSV
HBV envelope (348-357) (HLA-A*02:01) - GLSPTVWLSV peptide for stimulation of antigen-specific T cells in T cell assays such as ELISPOT, ICS, cytotoxity or proliferation assays.
From €85.50 * €90.00 *
HBV HBsAg (190-197) (H-2 Kb) - VWLSVIWM
HBV HBsAg (190-197) (H-2 Kb) - VWLSVIWM
HBV HBsAg (190-197) (H-2 Kb) - VWLSVIWM is a linear peptidic epitope (epitope ID71948) studied as part of Large envelope protein from Hepatitis B virus. This epitope has been studied for immune reactivity, tested in T cell assays and MHC...
From €85.50 * €90.00 *
HBV HBsAg (371-378) (H2-Kb) - IVSPFIPL
HBV HBsAg (371-378) (H2-Kb) - IVSPFIPL
HBV HBsAg (371-378) (H2-Kb) - IVSPFIPL is a linear peptidic epitope (epitope ID29454) studied as part of Large envelope protein from Hepatitis B virus. This epitope has been studied for immune reactivity, tested in T cell assays and MHC...
From €85.50 * €90.00 *
HCV NS3 (1406-1415) (HLA-A*02:01) KLSGLGINAV
HCV NS3 (1406-1415) (HLA-A*02:01) KLSGLGINAV
From €85.50 * €90.00 *
HCV NS5B (2594-2602) HLA-A*02:01 ALYDVVTKL
HCV NS5B (2594-2602) HLA-A*02:01 ALYDVVTKL
T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are typically peptides between 8 and 11 amino acids in length and exhibiting MHC-specific...
From €88.07 * €90.00 *
HER-2/neu (369-377) HLA-A*02:01 KIFGSLAFL
HER-2/neu (369-377) HLA-A*02:01 KIFGSLAFL
HER2 is the abbreviation for "human epidermal growth factor receptor 2". HER2 is often referred to as erbB2 or HER2 / neu. HER2 is a receptor on the surface of cells. Signals are transmitted from the cell surface to the cell nucleus via...
From €85.50 * €90.00 *
HER-2/neu (434-443) HLA-A*02:01 ILHDGAYSL
HER-2/neu (434-443) HLA-A*02:01 ILHDGAYSL
HER2 is the abbreviation for "human epidermal growth factor receptor 2". HER2 is often referred to as erbB2 or HER2 / neu. HER2 is a receptor on the surface of cells. Signals are transmitted from the cell surface to the cell nucleus via...
From €85.50 * €90.00 *
HER-2/neu (435-443) HLA-A*02:01 ILHNGAYSL
HER-2/neu (435-443) HLA-A*02:01 ILHNGAYSL
HER2 is the abbreviation for "human epidermal growth factor receptor 2". HER2 is often referred to as erbB2 or HER2 / neu. HER2 is a receptor on the surface of cells. Signals are transmitted from the cell surface to the cell nucleus via...
From €85.50 * €90.00 *
HER-2/neu (63-71) HLA-A*24:02 TYLPTNASL
HER-2/neu (63-71) HLA-A*24:02 TYLPTNASL
HER2 is the abbreviation for "human epidermal growth factor receptor 2". HER2 is often referred to as erbB2 or HER2 / neu. HER2 is a receptor on the surface of cells. Signals are transmitted from the cell surface to the cell nucleus via...
From €85.50 * €90.00 *
HIV-1 Gag (77-85) HLA-A*02:01 SLFNTVATL
HIV-1 Gag (77-85) HLA-A*02:01 SLFNTVATL
HIV-1 Gag (77-85) HLA-A*02:01 SLFNTVATL belongs to the T cell epitope peptides. T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are typically...
From €85.50 * €90.00 *
HIV-1 p17 Gag (77-85) HLA-A*02:01 SLYNTVATL
HIV-1 p17 Gag (77-85) HLA-A*02:01 SLYNTVATL
HIV-1 p17 Gag (77-85) SLYNTVATL belongs to the T cell epitope peptides. T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are typically peptides...
From €85.50 * €90.00 *
HPV 16 E7 (49-57) H-2 Db RAHYNIVTF
HPV 16 E7 (49-57) H-2 Db RAHYNIVTF
From €85.50 * €90.00 *
Influenza A MP (58-66) HLA-A*02:01 GILGFVFTL
Influenza A MP (58-66) HLA-A*02:01 GILGFVFTL
Influenza A MP (58-66) HLA-A*02:01 GILGFVFTL. T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are typically peptides between 8 and 11 amino...
From €85.50 * €90.00 *
Influenza A NP (366-374) - ASNENMETM
Influenza A NP (366-374) - ASNENMETM
Influenza A NP (366-374) - ASNENMETM. T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are typically peptides between 8 and 11 amino acids in...
From €85.50 * €90.00 *
LCVM GP (33-41) peptide sequence
LCMV GP (33-41) KAVYNFATM
LCMV GP (33-41) with the peptide sequence KAVYNFATM is a T-cell epitope peptide which is normally presented presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are...
From €88.07 * €90.00 *
MAGE-A3 (112-120) HLA-A*02:01 KVAEELVHFL - alternative sequence
MAGE-A3 (112-120) HLA-A*02:01 KVAEELVHFL -...
MAGE-A3 (112-120) HLA-A*02:01 KVAEELVHFL belongs to the group of T cell epitope peptides. T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are...
From €88.07 * €90.00 *
MAGE-A3 (112-120) HLA-A*02:01 KVAELVHFL
MAGE-A3 (112-120) HLA-A*02:01 KVAELVHFL
MAGE-A3 (112-120) HLA-A*02:01 KVAELVHFL belongs to the group of T cell epitope peptides. T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are...
From €85.50 * €90.00 *
MAGE-A3 (271-279) HLA-A*02:01 FLWGPRALV
MAGE-A3 (271-279) HLA-A*02:01 FLWGPRALV
MAGE-A3 (271-279) HLA-A*02:01 FLWGPRALV antigen belongs to the group of T cell epitope peptides. T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I...
From €85.50 * €90.00 *
MAGE-A3 Peptide Pool
MAGE-A3 Peptide Pool
MAGE-A3 Control Pool of 76peptides derived from a peptide scan (15mers with 11 aa overlap) through Melanoma-associated antigen 3 (MAGEA3) (UniProt ID: P43357) of Homo sapiens (Human) for T cell assay. Length of Melanoma-associated...
€210.00 *
MAGE-A4 (230–239) HLA-A*02:01 GVYDGREHTV
MAGE-A4 (230–239) HLA-A*02:01 GVYDGREHTV
MAGE-A4 (230–239) HLA-A*02:01 GVYDGREHTV belongs to the group of T cell epitope peptides. T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are...
From €88.07 * €90.00 *
Melan-A / MART-1 (26-35) - EAAGIGILTV
Melan-A / MART-1 (26-35) - EAAGIGILTV
T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are typically peptides between 8 and 11 amino acids in length and exhibiting MHC-specific...
From €85.50 * €90.00 *
Melan-A / MART-1 (26-35) EAAGIGILTV
Melan-A / MART-1 (26-35) EAAGIGILTV
T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are typically peptides between 8 and 11 amino acids in length and exhibiting MHC-specific...
From €85.50 * €90.00 *
MUC-1 (12-20) HLA-A*02:01 LLLLTVLTV
MUC-1 (12-20) HLA-A*02:01 LLLLTVLTV
MUC-1 (12-20) HLA-A*02:01 LLLLTVLTV belongs to the group of T cell epitope peptides. T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are...
From €88.07 * €90.00 *
MUC-1 (13-21) HLA-A*02:01 LLLTVLTVV
MUC-1 (13-21) HLA-A*02:01 LLLTVLTVV
MUC-1 (13-21) HLA-A*02:01 LLLTVLTVV belongs to the group of T cell epitope peptides. T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are...
From €88.07 * €90.00 *
OVA peptide SIINFEKL
Ova (257-264) SIINFEKL
Ovalbumin (257-264) chicken has been used to trigger T cell activation in immunology studies. T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules...
From €122.31 * €125.00 *
OVA peptide SIINFEKL
Ova (257-264) SIINFEKL amide
Ovalbumin (257-264) chicken has been used to trigger T cell activation in immunology studies. T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules...
From €122.31 * €125.00 *
Ova (323-339) ISQAVHAAHAEINEAGR
Ova (323-339) ISQAVHAAHAEINEAGR
T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are typically peptides between 8 and 11 amino acids in length and exhibiting MHC-specific...
From €153.83 *
Ova (323-339) ISQAVHAAHAEINEAGR - amide
Ova (323-339) ISQAVHAAHAEINEAGR - amide
T cell epitopes are presented on the surface of antigen-presenting cells by MHC molecules. T cell epitopes presented by MHC class I molecules are typically peptides between 8 and 11 amino acids in length and exhibiting MHC-specific...
From €225.06 * €230.00 *
p53 (264-272) HLA-A*0201 LLGRNSFEV
p53 (264-272) HLA-A*0201 LLGRNSFEV
Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous...
From €85.50 * €90.00 *
p53 (264-272) HLA-A*0201 LLGRNSFEV
p53 (264-272) HLA-A*0201 LLGRNSFEV
Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous...
From €85.50 * €90.00 *
PADRE - AKFVAAWTLKAAA
PADRE - AKFVAAWTLKAAA
The pan HLA DR-binding epitope (PADRE) has been proposed as a simple carrier epitope suitable for use in the development of synthetic and recombinant vaccines. T cell epitopes are presented on the surface of antigen-presenting cells by...
From €185.92 * €190.00 *
PRAME (100-108) HLA-A*0201 VLDGLDVLL
PRAME (100-108) HLA-A*0201 VLDGLDVLL
PRAME (100-108) HLA-A*0201 VLDGLDVLL for stimulation of human Prame (100-108) specific CD8+ T cells. The peptide is synthesised as it is presented by the MHC class I HLA-A*0201 allel.
From €85.50 * €90.00 *
PRAME (301-309) HLA-A24 LYVDSLFFL
PRAME (301-309) HLA-A24 LYVDSLFFL
From €85.50 * €90.00 *
RHAMM (165-173) HLA-A*0201 ILSLELMKL
RHAMM (165-173) HLA-A*0201 ILSLELMKL
RHAMM peptide ILSLELMKL (HLA-A*0201) for stimulation of human RHAMM -specific CD8+ T-cells. The peptide is synthesised as it is presented by the MHC class I HLA-A*0201 allele.
From €85.50 * €90.00 *
RSV NP (137-145) HLA-A*02:01 KMLKEMGEV
RSV NP (137-145) HLA-A*02:01 KMLKEMGEV
RSV NP (137-145) HLA-A*02:01 KMLKEMGEV is a linear peptidic epitope (epitope ID32357) studied as part of Nucleoprotein from Human respiratory syncytial virus. This epitope has been studied for immune reactivity, tested in T cell assays...
From €85.50 * €90.00 *
SART3 (309-317) HLA-A*02:01 RLAEYQAYI
SART3 (309-317) HLA-A*02:01 RLAEYQAYI
From €85.50 * €90.00 *
Tyrosinase (369-377) (371D) HLA-A*02:01 YMDGTMSQV
Tyrosinase (369-377) (371D) HLA-A*02:01 YMDGTMSQV
Tyrosinase (369-377) (371D) HLA-A*02:01 YMDGTMSQV for stimulation of T-cells. The single peptide (YMDGTMSQV) is used for stimulation of human gp100-specific CD8+ T-cells.
From €85.50 * €90.00 *
Tyrosinase (425-434) HLA-A*03:01 YMVPFIPLYR
Tyrosinase (425-434) HLA-A*03:01 YMVPFIPLYR
The similar peptide Tyrosinase (369-377) (371D) HLA-A*02:01 YMDGTMSQV (P3175 >) for stimulation of T-cells. The single peptide (YMDGTMSQV) is used for stimulation of human gp100-specific CD8+ T-cells.
From €85.50 * €90.00 *