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Produktinformationen "rec. Human Granulocyte Colony Stimulating Factor (rHu G-CSF)"
G-CSF is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Three transcript variants encoding three different isoforms have been found for the G-CSF gene. Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This csf induces granulocytes.
Rec. human Granulocyte Colony Stimulating Factor produced in E.coli is a single, non-glycosylated, polypeptide chain of 175 amino acids and a molecular mass of 18.8 KDa.
Biological activity: The ED50, calculated by the dose-dependant proliferation of murine NFS-60 indicator cells (measured by 3H-thymidine uptake) is <0.1ng/mL, corresponding to a Specific Activity of 100,000,000 IU/mg.
Synonyms: CSF-3, MGI-1G, GM-CSF beta, Pluripoietin, Filgrastim, Lenograstim, G-CSF, MGC45931, GCSF.
Specifications:
Purity: >98% (HPLC, SDS-PAGE)
GCSF was lyophilized after extensive dialysis against 10mM sodium acetate buffer pH=4.
First five amino acids: Met-Thr-Pro-Leu-Gly.
Quelle:
Escherichia Coli.Klassifizierungen:
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