Advantages at a glance
- Purity: >95% (HPLC)
- Sequence: VMAPRTLIL
- HLA-B*08:01
product.PriceLabel
| Quantity | Unit price |
|---|---|
| To 2 |
€169.00
|
| From 3 |
€126.75
€169.00
(25% saved)
|
Delivery time 3–8 days
Product number:
P2670.9501
Delivery time:
2-5 days
Our benefits
- Free shipping
- Shipping within 24h
- 30 days money back guarantee
- Purchase comfortable on account
For precise information regarding the delivery date, please contact Genaxxon.
Product information "HCMV UL40 15-23 (HLA-E) - VMAPRTLIL"
HCMV UL40 15-23 acts as an important negative regulator of natural killer cell activity. For this the HCMV UL40 15-23 peptide (epitope ID69921) is often used as positive control.
HCMV UL40 15-23 is part of the immune evasion strategie of the Human Cytomegalovirus (HCMV). The virus downregulates HLA class Ia molecule expression in order to evade T cell recognition. However, a lack of surface HLA class Ia molecules triggers cytotoxicity of Natural Killer (NK) cells. To counteract this effect, the Cytomegalovirus promotes upregulation of HLA-E and provides the peptide HCMV UL40 15-23 (VMAPRTLIL), which is identical with the leader sequence of HLA-Cw03 (VMAPRTLIL). When loaded onto HLA-E, this peptide conferres resistance to NK cell lysis via the CD94/NKG2A receptor.
HLA-E is presenting peptides derived from self-proteomic content and peptides of pathogenic origin.
VMAPRTLIL is part of the following proteins of human origin:
- Major histocompatibility complex, class I, C (UniProt:A0A140T9M0, A0A140T9U0, A0A0G2JH50, A0A140T912 and A0A140T9Z4)
- HLA class I histocompatibility antigen C alpha chain (UniProt:Q53YP1, Q5RIP0)
- HLA class I antigen (UniProt:Q5QT33)
- Isoform 2 of HLA class I histocompatibility antigen, C alpha chain (UniProt:P10321-2)
- Major histocompatibility complex, class I, C (UniProt:A0A140T9M0, A0A140T9U0, A0A0G2JH50, A0A140T912 and A0A140T9Z4)
- HLA class I histocompatibility antigen C alpha chain (UniProt:Q53YP1, Q5RIP0)
- HLA class I antigen (UniProt:Q5QT33)
- Isoform 2 of HLA class I histocompatibility antigen, C alpha chain (UniProt:P10321-2)
Specifications:
Purity: >95% (HPLC)
Sequence: VMAPRTLIL
HLA-B*08:01
Lyophilized white powder
Documents - Protocols - Downloads :
Here you will find information and further literature. For further documents (certificates with additional lot numbers, safety data sheets in other languages, further product information) please contact Genaxxon biosience at: info@genaxxon.com or phone: +49 731 3608 123.